User profiles for Harald H.H.W Schmidt
 | Harald HHW SchmidtProfessor & Chair of Pharmacology and Personalised Medicine, University of Maastricht Verified email at maastrichtuniversity.nl Cited by 39749 |
NO at work
HHHW Schmidt, U Walter - Cell, 1994 - Elsevier
Nitroglycerine has been used for over a century to treat coronary heart disease, and it has
long been suggested that humans synthesize oxides of nitrogen (Mitchell et al., 1916). These …
long been suggested that humans synthesize oxides of nitrogen (Mitchell et al., 1916). These …
[HTML][HTML] Network pharmacology: curing causal mechanisms instead of treating symptoms
For complex diseases, most drugs are highly ineffective, and the success rate of drug
discovery is in constant decline. While low quality, reproducibility issues, and translational …
discovery is in constant decline. While low quality, reproducibility issues, and translational …
NO-independent stimulators and activators of soluble guanylate cyclase: discovery and therapeutic potential
Soluble guanylate cyclase (sGC) is a key signal-transduction enzyme activated by nitric
oxide (NO). Impaired bioavailability and/or responsiveness to endogenous NO has been …
oxide (NO). Impaired bioavailability and/or responsiveness to endogenous NO has been …
The nitric oxide and cGMP signal transduction system: regulation and mechanism of action
A wide spectrum of ligands, including hormones, autacoids, drugs and toxins, have cGMP
as their common mediator in eliciting diverse physiological responses. Signal transduction …
as their common mediator in eliciting diverse physiological responses. Signal transduction …
Clinical relevance of biomarkers of oxidative stress
Significance: Oxidative stress is considered to be an important component of various diseases.
A vast number of methods have been developed and used in virtually all diseases to …
A vast number of methods have been developed and used in virtually all diseases to …
Apocynin is not an inhibitor of vascular NADPH oxidases but an antioxidant
…, S Wind, E Barbosa-Sicard, HHHW Schmidt… - …, 2008 - Am Heart Assoc
A large body of literature suggest that vascular reduced nicotinamide-adenine dinucleotide
phosphate (NADPH) oxidases are important sources of reactive oxygen species. Many …
phosphate (NADPH) oxidases are important sources of reactive oxygen species. Many …
Cloned human brain nitric oxide synthase is highly expressed in skeletal muscle
M Nakane, HHHW Schmidt, JS Pollock… - FEBS …, 1993 - Wiley Online Library
Complementary DNA clones corresponding to human brain nitric oxide (NO) synthase have
been isolated. The deduced amino acid sequence revealed an overall identity with rat brain …
been isolated. The deduced amino acid sequence revealed an overall identity with rat brain …
[HTML][HTML] Direct interaction of the novel Nox proteins with p22phox is required for the formation of a functionally active NADPH oxidase
Nox1 and Nox4, homologues of the leukocyte NADPH oxidase subunit Nox2 (gp91phox)
mediate superoxide anion formation in various cell types. However, their interactions with other …
mediate superoxide anion formation in various cell types. However, their interactions with other …
[HTML][HTML] Targeting the heme-oxidized nitric oxide receptor for selective vasodilatation of diseased blood vessels
JP Stasch, PM Schmidt, PI Nedvetsky… - The Journal of …, 2006 - Am Soc Clin Investig
… Schmidt was employed from 2000 to 2003 by Bayer HealthCare. Harald Lapp is the
principal … Harald HHW Schmidt is coinventor of a patent on the use of human sGC, owned by …
principal … Harald HHW Schmidt is coinventor of a patent on the use of human sGC, owned by …
Evolution of NADPH oxidase inhibitors: selectivity and mechanisms for target engagement
…, PWM Kleikers, K Wingler, HHHW Schmidt - Antioxidants & redox …, 2015 - liebertpub.com
Significance: Oxidative stress, an excess of reactive oxygen species (ROS) production versus
consumption, may be involved in the pathogenesis of different diseases. The only known …
consumption, may be involved in the pathogenesis of different diseases. The only known …