Microfabrication of a BioModule composed of microfluidics and digitally controlled microelectrodes for processing biomolecules

…, U Tangen, T Maeke, HP Mathis… - Smart materials and …, 2003 - iopscience.iop.org
This work focuses on the development of an online programmable microfluidic bioprocessing
unit (BioModule) using digital logic microelectrodes for rapid pipelined selection and …

[HTML][HTML] The Mean Single Molecule Rate (mSMR) in the Analysis of Fluorescence Fluctuations: Measurements on DNA Mixtures of Defined Composition

LT Sparrenberg, B Greiner, HP Mathis - Journal of Fluorescence, 2021 - Springer
We present a method for the evaluation of fluorescence fluctuations on the basis of Mandel’s
Q parameter, using sampling time-dependent factorial cumulants. By relating the Q …

Time-resolved measurements of DNA interactions in an electrowetting-on-dielectric system using confocal microscopy

…, B Greiner, C Mueller, HP Mathis - Journal of Physics …, 2017 - iopscience.iop.org
To identify new drug candidates a deep and profound knowledge of molecule interactions is
needed. In the current work, a combination of an electrowetting-on-dielectric (EWOD) …

Construction of an integrated biomodule composed of microfluidics and digitally controlled microelectrodes for processing biomolecules

…, U Tangen, T Maeke, HP Mathis… - Microfluidics …, 2003 - spiedigitallibrary.org
This work focuses on the development of an online programmable microfluidic bioprocessing
unit (BioModule) using digital logic microelectrodes for rapid pipelined selection and …

Integrated microfluidic diagnostic platform for marker and environmental detection

HP Mathis, C Müller, B Greiner… - Single Molecule …, 2008 - spiedigitallibrary.org
The interdisciplinary project IMIKRID targets the "proof of concept" of a novel technological
platform for the development of customised complete diagnostic systems of ultra high …

Single molecule detection for in vitro diagnostics

T Kirner, J Ackermann, HP Mathis… - Single Molecule …, 2008 - spiedigitallibrary.org
In this paper we present a novel highly sensitive detection system for diagnostic applications.
The system is designed to meet the needs of medical diagnostics for reliable …

[HTML][HTML] Bleaching correction for DNA measurements in highly diluted solutions using confocal microscopy

LT Sparrenberg, B Greiner, HP Mathis - Plos one, 2020 - journals.plos.org
Determining the concentration of nucleic acids in biological samples precisely and reliably
still is a challenge. In particular when only very small sample quantities are available for …

Projection of an immunological self shadow within the thymus by the aire protein

…, R Bronson, A Dierich, C Benoist, D Mathis - Science, 2002 - science.org
Humans expressing a defective form of the transcription factor AIRE (autoimmune regulator)
develop multiorgan autoimmune disease. We used aire- deficient mice to test the …

Molecular systems on-chip (MSoC) steps forward for programmable biosystems

PF Wagler, U Tangen, T Maeke… - … and Materials 2004 …, 2004 - spiedigitallibrary.org
This work describes online programmable microfluidic bioprocessing units using digital
logic microelectrodes for rapid pipelined translocation of DNA molecules and other charged …

Miniaturized electrocaloric flow controller for analyte multiplexing and cell/particle sorting

…, S Poser, E Ermantraut, J McCaskill, H Mathis… - Micro Total Analysis …, 1998 - Springer
In the growing field of microsystems for analysis systems there is a major need of simple
and stable micro devices to manipulate and switch fluid currents. Common devices use …