[HTML][HTML] A first-in-class fully modified version of miR-34a with outstanding stability, activity, and anti-tumor efficacy
Altered by defects in p53, epigenetic silencing, and genomic loss, the microRNA miR-34a
represents one of the most clinically relevant tumor-suppressive microRNAs. Without question, …
represents one of the most clinically relevant tumor-suppressive microRNAs. Without question, …
Story-map: iPad companion for long form TV narratives
…, J Cutrell, A Doris-Down, H Kothandaraman - Proceedings of the 10th …, 2012 - dl.acm.org
Long form TV narratives present multiple continuing characters and story arcs that last over
multiple episodes and even over multiple seasons. Writers increasingly take pride in creating …
multiple episodes and even over multiple seasons. Writers increasingly take pride in creating …
[HTML][HTML] cTULIP: application of a human-based RNA-seq primary tumor classification tool for cross-species primary tumor classification in canine
…, SE Jones, H Kothandaraman… - Frontiers in …, 2023 - ncbi.nlm.nih.gov
Methods In this study, we take a deep-learning approach to test how similar the gene
expression profile of canine glioma and bladder cancer (BLCA) tumors are to the corresponding …
expression profile of canine glioma and bladder cancer (BLCA) tumors are to the corresponding …
Understanding the Natural Language of DNA using Encoder-Decoder Foundation Models with Byte-level Precision
A Malusare, H Kothandaraman, D Tamboli… - arXiv preprint arXiv …, 2023 - arxiv.org
This paper presents the Ensemble Nucleotide Byte-level Encoder-Decoder (ENBED)
foundation model, analyzing DNA sequences at byte-level precision with an encoder-decoder …
foundation model, analyzing DNA sequences at byte-level precision with an encoder-decoder …
KRAS-mediated upregulation of CIP2A promotes suppression of PP2A-B56α to initiate pancreatic cancer development
Oncogenic mutations in KRAS are present in approximately 95% of patients diagnosed with
pancreatic ductal adenocarcinoma (PDAC) and are considered the initiating event during …
pancreatic ductal adenocarcinoma (PDAC) and are considered the initiating event during …
First near complete haplotype phased genome assembly of River buffalo (Bubalus bubalis)
S Ananthasayanam, H Kothandaraman, N Nayee… - BioRxiv, 2019 - biorxiv.org
This study reports the first haplotype phased reference quality genome assembly of ‘Murrah’
an Indian breed of river buffalo. A mother-father-progeny trio was used for sequencing so …
an Indian breed of river buffalo. A mother-father-progeny trio was used for sequencing so …
[HTML][HTML] Comparative transcriptome profiling of pomegranate genotypes having resistance and susceptible reaction to Xanthomonas axonopodis pv. punicae
…, A Tripathi, SK Peddamma, H Kothandaraman… - Saudi Journal of …, 2020 - Elsevier
Pomegranate (Punica granatum L.) is an important fruit crop, rich in fiber, vitamins, antioxidants,
minerals and source of different biologically active compounds. The bacterial blight …
minerals and source of different biologically active compounds. The bacterial blight …
The Cuon Enigma: Genome survey and comparative genomics of the endangered Dhole (Cuon alpinus)
…, V Singh, B Kumar, A Tripathi, H Kothandaraman… - BioRxiv, 2018 - biorxiv.org
The Asiatic wild dog is an endangered monophyletic canid restricted to Asia; facing threats
from habitat fragmentation and other anthropogenic factors. Dholes have unique adaptations …
from habitat fragmentation and other anthropogenic factors. Dholes have unique adaptations …
Alterations in the tumor microenvironment and key signaling pathways in naturally-occurring canine gliomas mirror those seen in human patients
NA Lanman, S Utturkar, H Kothandaraman, D Dhawan… - Cancer Research, 2024 - AACR
Background: Malignant gliomas are the most common type of primary brain tumors, with
patient outcomes that are generally dismal. Recently, pet dogs have been assessed as a …
patient outcomes that are generally dismal. Recently, pet dogs have been assessed as a …
High coverage genome sequencing and identification of genomic variants in Bengal tiger (Panthera tigris tigris)
P Anuradha Reddy, H Kothandaraman… - bioRxiv, 2018 - biorxiv.org
Bengal tiger (Panthera tigris tigris), one of six extant tiger subspecies, occurs solely in the
Indian subcontinent. Although endangered and threatened by various extinction risks, this is …
Indian subcontinent. Although endangered and threatened by various extinction risks, this is …