Phosphorylation of types III and IV intermediate filaments (IFs) is known to regulate their
organization and function. Phosphorylation of the amino-terminal head domain sites on types III …

Amyotrophic lateral sclerosis (ALS) is increasingly considered to be a disorder of multiple
etiologies that have in common progressive degeneration of both upper and lower motor …

Alzheimer’s disease (AD), the most devastating chronic neurodegenerative disease in
adults, causes dementia and eventually, death of the affected individuals. Clinically, AD is …

Although cyclin-dependent kinase 5 (Cdk5) is closely related to other cyclin-dependent
kinases, its kinase activity is detected only in the postmitotic neurons. Cdk5 expression and …

It has been demonstrated that oxidative stress has a ubiquitous role in neurodegenerative
diseases. Major source of oxidative stress due to reactive oxygen species (ROS) is related to …

Recent studies have shown that there exists a family of protein kinases structurally and
functionally related to the yeast cell cycle regulatory kinase cdc2 [Meyerson, M., Faha, B., Su, L.-K.…

Members of the N-methyl-d-aspartate (NMDA) class of glutamate receptors (NMDARs) are
critical for development, synaptic transmission, learning and memory; they are targets of …

Neuronal transmission of information requires polarized distribution of membrane proteins
within axonal compartments. Membrane proteins are synthesized and packaged in membrane…

The transglutaminase (TGase) family of enzymes, of which seven different members are
known in the human genome, participate in many biological processes involving cross-linking …

The extracellular aggregation of amyloid β (Aβ) peptides and the intracellular hyperphosphorylation
of tau at specific epitopes are pathological hallmarks of neurodegenerative diseases …