[HTML][HTML] Oncogenic mutations of PIK3CA lead to increased membrane recruitment driven by reorientation of the ABD, p85 and C-terminus
ML Jenkins, H Ranga-Prasad, MAH Parson… - Nature …, 2023 - nature.com
PIK3CA encoding the phosphoinositide 3-kinase (PI3K) p110α catalytic subunit is frequently
mutated in cancer, with mutations occurring widely throughout the primary sequence. The …
mutated in cancer, with mutations occurring widely throughout the primary sequence. The …
Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain
…, MK Rathinaswamy, MAH Parson, H Ranga-Prasad… - Elife, 2023 - elifesciences.org
PI3Kγ is a critical immune signaling enzyme activated downstream of diverse cell surface
molecules, including Ras, PKCβ activated by the IgE receptor, and Gβγ subunits released from …
molecules, including Ras, PKCβ activated by the IgE receptor, and Gβγ subunits released from …
[PDF][PDF] Molecular basis for differential activation of p101 and p84 complexes of PI3Kγ by Ras and GPCRs
…, JTB Stariha, U Dalwadi, KD Fleming, H Ranga-Prasad… - Cell Reports, 2023 - cell.com
Class IB phosphoinositide 3-kinase (PI3Kγ) is activated in immune cells and can form two
distinct complexes (p110γ-p84 and p110γ-p101), which are differentially activated by G protein…
distinct complexes (p110γ-p84 and p110γ-p101), which are differentially activated by G protein…
[HTML][HTML] Disrupting Plasmodium UIS3–host LC3 interaction with a small molecule causes parasite elimination from host cells
…, FJ Enguita, ÂF Chora, H Ranga-Prasad… - Communications …, 2020 - nature.com
The malaria parasite Plasmodium obligatorily infects and replicates inside hepatocytes
surrounded by a parasitophorous vacuole membrane (PVM), which is decorated by the host-cell …
surrounded by a parasitophorous vacuole membrane (PVM), which is decorated by the host-cell …
[HTML][HTML] Association of Plasmodium berghei With the Apical Domain of Hepatocytes Is Necessary for the Parasite's Liver Stage Development
Plasmodium parasites undergo a dramatic transformation during the liver stage of their life
cycle, amplifying over 10,000-fold inside infected hepatocytes within a few days. Such a rapid …
cycle, amplifying over 10,000-fold inside infected hepatocytes within a few days. Such a rapid …
Understanding the molecular basis of regulation of class I PI3Ks by activation signals, oncogenic mutations, and post-translational modifications
H Ranga Prasad - 2022 - dspace.library.uvic.ca
Class I Phosphoinostide-3 Kinases (PI3K) generate Phosphatidylinositol-3, 4, 5 Trisphosphate
(PIP3), which regulates important cellular tasks such as proliferation, cell growth, survival …
(PIP3), which regulates important cellular tasks such as proliferation, cell growth, survival …
[HTML][HTML] Autophosphorylation of serine 608 in the p85 regulatory subunit of wild type or cancer-associated mutants of phosphoinositide 3-kinase does not affect its lipid …
MJ Layton, M Saad, NL Church, RB Pearson… - Bmc Biochemistry, 2012 - Springer
Background The α-isoform of the Type 1A Phosphoinositide 3-kinases (PI3Kα) has protein
kinase activity as well as phosphoinositide lipid kinase activity. The best described substrate …
kinase activity as well as phosphoinositide lipid kinase activity. The best described substrate …
Risk factors and comorbidities in young Indian patients with hypertension: REAL YOUNG (Hypertension) study
N Desai, G Unni, R Agarwala, S Salagre… - Integrated Blood …, 2021 - Taylor & Francis
Purpose To analyze the risk factors and comorbidities among the young Indian adults with
hypertension. Patients and Methods This was a retrospective, multicentric real-world study …
hypertension. Patients and Methods This was a retrospective, multicentric real-world study …
Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit
N Miled, Y Yan, WC Hon, O Perisic, M Zvelebil, Y Inbar… - science, 2007 - science.org
Many human cancers involve up-regulation of the phosphoinositide 3-kinase PI3Kα, with
oncogenic mutations identified in both the p110α catalytic and the p85α regulatory subunits. …
oncogenic mutations identified in both the p110α catalytic and the p85α regulatory subunits. …
Central role for G protein-coupled phosphoinositide 3-kinase γ in inflammation
Phosphoinositide 3-kinase (PI3K) activity is crucial for leukocyte function, but the roles of the
four receptor-activated isoforms are unclear. Mice lacking heterotrimeric guanine nucleotide-…
four receptor-activated isoforms are unclear. Mice lacking heterotrimeric guanine nucleotide-…