Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix

…, D Sheppard, HA Chapman - Proceedings of the …, 2006 - National Acad Sciences
Mechanisms leading to fibroblast accumulation during pulmonary fibrogenesis remain unclear.
Although there is in vitro evidence of lung alveolar epithelial-to-mesenchymal transition (…

Pycnodysostosis, a lysosomal disease caused by cathepsin K deficiency

BD Gelb, GP Shi, HA Chapman, RJ Desnick - Science, 1996 - science.org
Pycnodysostosis, an autosomal recessive osteochondrodysplasia characterized by osteosclerosis
and short stature, maps to chromosome 1q21. Cathepsin K, a cysteine protease gene …

Emerging roles for cysteine proteases in human biology

HA Chapman, RJ Riese, GP Shi - Annual review of physiology, 1997 - annualreviews.org
▪ Abstract Cysteine proteases have traditionally been viewed as lysosomal mediators of
terminal protein degradation. However, recent findings refute this limited view and suggest a …

Regulation of integrin function by the urokinase receptor

…, SC Bodary, S Rosenberg, MV Doyle, HA Chapman - Science, 1996 - science.org
Integrin function is central to inflammation, immunity, and tumor progression. The urokinase-type
plasminogen activator receptor (uPAR) and integrins formed stable complexes that both …

Expression of the elastolytic cathepsins S and K in human atheroma and regulation of their production in smooth muscle cells.

…, GP Shi, DI Simon, HA Chapman… - The Journal of …, 1998 - Am Soc Clin Investig
Formation of the atherosclerotic intima must involve altered metabolism of the elastin-rich
arterial extracellular matrix. Proteases potentially involved in these processes remain unclear. …

[PDF][PDF] Repair and regeneration of the respiratory system: complexity, plasticity, and mechanisms of lung stem cell function

BLM Hogan, CE Barkauskas, HA Chapman, JA Epstein… - Cell stem cell, 2014 - cell.com
Respiratory disease is the third leading cause of death in the industrialized world. Consequently,
the trachea, lungs, and cardiopulmonary vasculature have been the focus of extensive …

[HTML][HTML] Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase–and cathepsin-dependent emphysema

…, B Ma, RJ Riese, HA Chapman… - The Journal of …, 2000 - Am Soc Clin Investig
Cigarette smoke exposure is the major cause of chronic obstructive pulmonary disease (COPD).
However, only a minority of smokers develop significant COPD, and patients with …

The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor

…, BL Lee, L Lau, KE Wickliffe, GP Shi, HA Chapman… - Nature, 2008 - nature.com
Mammalian Toll-like receptors (TLRs) 3, 7, 8 and 9 initiate immune responses to infection
by recognizing microbial nucleic acids 1 , 2 ; however, these responses come at the cost of …

B lymphocytes are essential for the initiation of T cell-mediated autoimmune diabetes: analysis of a new" speed congenic" stock of NOD. Ig mu null mice.

DV Serreze, HD Chapman, DS Varnum… - The Journal of …, 1996 - rupress.org
The T lymphocytes mediating autoimmune destruction of pancreatic beta cells in the
nonobese diabetic (NOD) mouse model of insulin-dependent diabetes mellitus (IDDM) may be …

[PDF][PDF] Essential role for cathepsin S in MHC class II–associated invariant chain processing and peptide loading

…, LR Natkin, JA Villadangos, HL Ploegh, HA Chapman - Immunity, 1996 - cell.com
Destruction of Ii by proteolysis is required for MHC class II molecules to bind antigenic
peptides, and for transport of the resulting complexes to the cell surface. The cysteine protease …