Intercellular adhesion molecule-1 (ICAM-1) is greatly up-regulated on endothelial cells at sites
of inflammation and is involved in leukocyte attachment and extravasation. Previously, we …

Conformational conversion of proteins in disease is likely to be accompanied by molecular
surface exposure of previously sequestered amino-acid side chains. We found that induction …

The objectives of these studies were to investigate and compare solid lipid nanoparticles (SLNs)
of two anthracyclines, idarubicin (IDA) and doxorubicin (DOX), against Pgp-mediated …

Innervation plays a pivotal role as a driver of tissue and organ development as well as a
means for their functional control and modulation. Therefore, innervation should be carefully …

Functional restoration following major peripheral nerve injury (PNI) is challenging, given slow
axon growth rates and eventual regenerative pathway degradation in the absence of axons…

Mammalian artificial chromosomes (MACs) provide a means to introduce large payloads of
genetic information into the cell in an autonomously replicating, non-integrating format. …

Strategies to accelerate the rate of axon regeneration would improve functional recovery
following peripheral nerve injury, in particular for cases involving segmental nerve defects. We …

BACKGROUND Millions of Americans experience residual deficits from traumatic peripheral
nerve injury (PNI). Despite advancements in surgical technique, repair typically results in …

Purpose. A plasmid-based gene expression system was complexed with protective, interactive,
and non-condensing (PINC™) polymer system and administered with Medi-Jector™, a …

Positive human clinical data using biolistic-mediated gene transfer (ie, gene gun) to
administer a nucleic acid-based Hepatitis B vaccine has validated genetic immunization as an …