Plasticity of the cell state has been proposed to drive resistance to multiple classes of cancer
therapies, thereby limiting their effectiveness 1 , 2 , 3 , 4 . A high-mesenchymal cell state …

Acquired drug resistance prevents cancer therapies from achieving stable and complete
responses 1 . Emerging evidence implicates a key role for non-mutational drug resistance …

Purpose: Glioblastoma is the most frequent and lethal primary brain tumor. Development of
novel therapies relies on the availability of relevant preclinical models. We have established …

Effective treatment of glioblastoma multiforme remains a major clinical challenge, due in part
to the difficulty of delivering chemotherapeutics across the blood–brain barrier. Systemically …

Pre-analytical factors can significantly affect circulating cell-free DNA (cfDNA) analysis.
However, there are few robust methods to rapidly assess sample quality and the impact of pre-…

Purpose: AZD1775 is a first-in-class Wee1 inhibitor with dual function as a DNA damage
sensitizer and cytotoxic agent. A phase I study of AZD1775 for solid tumors suggested activity …

Background Glioblastoma (GBM) is the most common and aggressive primary brain tumor.
Prognosis remains poor despite multimodal therapy. Developing alternative treatments is …

Glioblastoma multiforme (GBM) is the most common brain malignancies in adults. Most GBM
patients succumb to the disease less than 1 year after diagnosis due to the highly invasive …

Histology of malignant glioma depicts dense proliferative areas rich in angiogenesis as well
as dissemination of neoplastic cells into adjacent brain tissue. Although the mechanisms …

The survival of patients diagnosed with glioblastoma (GBM), the most deadly form of brain
cancer, is compromised by the proclivity for local invasion into the surrounding normal brain, …