Cellular oncogenes and multistep carcinogenesis

H Land, LF Parada, RA Weinberg - Science, 1983 - science.org
Two dozen cellular proto-oncogenes have been discovered to date through the study of
retroviruses and the use of gene transfer. They form a structurally and functionally …

Induction of apoptosis in fibroblasts by c-myc protein

GI Evan, AH Wyllie, CS Gilbert, TD Littlewood, H Land… - Cell, 1992 - cell.com
Although Rat-l fibroblasts expressing c-myc constitutively are unable to arrest growth in low
serum, their numbers do not increase in culture because of substantial cell death. We show …

Myc—Max—Mad: a transcription factor network controlling cell cycle progression, differentiation and death

B Amati, H Land - Current opinion in genetics & development, 1994 - Elsevier
The Myc oncoprotein dimerizes with its partner, Max, to bind DNA, activate transcription, and
promote cell proliferation, as well as programmed cell death. Max also forms homodimers …

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

JP Morgenstern, H Land - Nucleic acids research, 1990 - academic.oup.com
We report the development of an advanced system for transfer and expression of exogenous
genes in mammalian cells based on Moloney murine leukemia virus (Mo MuLV). Extensive …

Oncogenic activity of the c-Myc protein requires dimerization with Max

…, MW Brooks, N Levy, TD Littlewood, GI Evan, H Land - Cell, 1993 - cell.com
c-Myc (Myc) and Max proteins dimerize and bind DNA through basic-helix-loop-helix-leucine
zipper motifs (b-HLH-LZ). Using a genetic approach, we demonstrate that binding to Max is …

[PDF][PDF] Anticancer activity of the cholesterol exporter ABCA1 gene

B Smith, H Land - Cell reports, 2012 - cell.com
The ABCA1 protein mediates the transfer of cellular cholesterol across the plasma membrane
to apolipoprotein AI. Loss-of-function mutations in the ABCA1 gene induce Tangier …

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

H Land, LF Parada, RA Weinberg - Nature, 1983 - nature.com
Transfection of embryo fibroblasts by a human ras oncogene does not convert them into
tumour cells unless the fibroblasts are established and immortalized before transfection. The …

Integrated control of cell proliferation and cell death by the c-myc oncogene

…, E Harrington, A Fanidi, H Land… - … of the Royal …, 1994 - royalsocietypublishing.org
Regulation of multicellular architecture involves a dynamic equilibrium between cell
proliferation, differentiation with consequent growth arrest, and cell death. Apoptosis is one …

Cooperation between gene encoding p53 tumour antigen and ras in cellular transformation

LF Parada, H Land, RA Weinberg, D Wolf, V Rotter - Nature, 1984 - nature.com
The protein p53 is highly expressed in a large variety of transformed cell types originating
from diverse species. These include cells transformed by Simian virus 40 (SV40), adenovirus …

Nucleotide sequence of cloned cDNA encoding bovine arginine vasopressin–neurophysin II precursor

H Land, G Schütz, H Schmale, D Richter - Nature, 1982 - nature.com
The sequence of a cDNA encoding the nonapeptide arginine vasopressin (A VP) and its
carrier protein, neurophysin II (NpII) from bovine hypothalamus, proves that the 166-amino acid …