In situ cryo electron tomography of cryo focused ion beam milled samples has emerged in
recent years as a powerful technique for structural studies of macromolecular complexes in …

Cryo-electron microscopy (cryo-EM) has emerged as a powerful structure determination
technique. Its most prolific branch is single particle analysis (SPA), a method being used in a …

Existence of cellular structures with specific size raises a fundamental question in biology:
How do cells measure length? One conceptual answer to this question is by a molecular ruler, …

Cilia/flagella are conserved organelles that generate fluid flow in eukaryotes. The bending
motion of flagella requires concerted activity of dynein motors. Although it has been reported …

Maintenance of cell volume against osmotic change is crucial for proper cell functions.
Leucine-rich repeat-containing 8 proteins are anion-selective channels that extrude anions to …

In stacking-based supramolecular polymerization, chiral hydrogen bonding (H-bonding)
monomers often prefer to adapt a homochiral monomer sequence. Herein, we investigated the …

10.7554/eLife.01566.001 Cilia/flagella are assembled and maintained by the process of
intraflagellar transport (IFT), a highly conserved mechanism involving more than 20 IFT proteins. …

Centrioles are cylindrical, ninefold symmetrical structures with peripheral triplet microtubules
strictly required to template cilia and flagella. The highly conserved protein SAS-6 …

Linearly conjugated systems have long served as an archetype of conjugated materials, but
suffer from two intrinsic structural problems: potential instability due to intermolecular …

The axoneme—the conserved core of eukaryotic cilia and flagella—contains highly specialized
doublet microtubules (DMTs). A long-standing question is what protein(s) compose the …