User profiles for Harukazu Suzuki

harukazu suzuki

Group Director, RIKEN CLST
Verified email at gsc.riken.jp
Cited by 41159

A comprehensive survey of 3′ animal miRNA modification events and a possible role for 3′ adenylation in modulating miRNA targeting effectiveness

…, T Funakoshi, T Kurokawa, H Suzuki… - Genome …, 2010 - genome.cshlp.org
Animal microRNA sequences are subject to 3′ nucleotide addition. Through detailed analysis
of deep-sequenced short RNA data sets, we show adenylation and uridylation of miRNA …

An atlas of active enhancers across human cell types and tissues

…, M Boyd, Y Chen, X Zhao, C Schmidl, T Suzuki… - Nature, 2014 - nature.com
Enhancers control the correct temporal and cell-type-specific activation of gene expression
in multicellular eukaryotes. Knowing their properties, regulatory activity and targets is crucial …

Genome-wide analysis of mammalian promoter architecture and evolution

…, A Chesi, S Gustincich, F Persichetti, H Suzuki… - Nature …, 2006 - nature.com
Mammalian promoters can be separated into two classes, conserved TATA box–enriched
promoters, which initiate at a well-defined site, and more plastic, broad and evolvable CpG-…

Structural parts involved in activation and inactivation of the sodium channel

W Stühmer, F Conti, H Suzuki, X Wang, M Noda… - Nature, 1989 - nature.com
Abstract Structure–function relationships of the sodium channel expressed inXenopus
oocytes have been investigated by the combined use of site–directed mutagenesis and patch-…

Enhanced identification of transcriptional enhancers provides mechanistic insights into diseases

…, H Kawaji, M Nishikawa, H Zayed, H Suzuki… - Trends in Genetics, 2016 - cell.com
Enhancers are distal cis-regulatory DNA elements that increase the expression of target
genes. Various experimental and computational approaches including chromatin signature …

An atlas of human long non-coding RNAs with accurate 5′ ends

…, M Babina, CA Wells, S Kojima, Y Nakamura, H Suzuki… - Nature, 2017 - nature.com
Long non-coding RNAs (lncRNAs) are largely heterogeneous and functionally uncharacterized.
Here, using FANTOM5 cap analysis of gene expression (CAGE) data, we integrate …

Existence of distinct sodium channel messenger RNAs in rat brain

M Noda, T Ikeda, T Kayano, H Suzuki, H Takeshima… - Nature, 1986 - nature.com
The sodium channel is a voltage-gated ionic channel essential for the generation of action
potentials 1–3 . It has been reported that the sodium channels purified from the electric organ …

The regulated retrotransposon transcriptome of mammalian cells

…, H Takahashi, J Kawai, ARR Forrest, H Suzuki… - Nature …, 2009 - nature.com
Although repetitive elements pervade mammalian genomes, their overall contribution to
transcriptional activity is poorly defined. Here, as part of the FANTOM4 project, we report that 6–…

High-throughput mapping of a dynamic signaling network in mammalian cells

…, IW Taylor, V Luga, N Przulj, M Robinson, H Suzuki… - Science, 2005 - science.org
Signaling pathways transmit information through protein interaction networks that are
dynamically regulated by complex extracellular cues. We developed LUMIER (for luminescence-…

[HTML][HTML] An atlas of combinatorial transcriptional regulation in mouse and man

T Ravasi, H Suzuki, CV Cannistraci, S Katayama… - Cell, 2010 - cell.com
Combinatorial interactions among transcription factors are critical to directing tissue-specific
gene expression. To build a global atlas of these combinations, we have screened for …