[PDF][PDF] A single CRISPR-Cas9 deletion strategy that targets the majority of DMD patients restores dystrophin function in hiPSC-derived muscle cells
CS Young, MR Hicks, NV Ermolova, H Nakano, M Jan… - Cell stem cell, 2016 - cell.com
Mutations in DMD disrupt the reading frame, prevent dystrophin translation, and cause
Duchenne muscular dystrophy (DMD). Here we describe a CRISPR/Cas9 platform applicable to …
Duchenne muscular dystrophy (DMD). Here we describe a CRISPR/Cas9 platform applicable to …
[HTML][HTML] Haemogenic endocardium contributes to transient definitive haematopoiesis
H Nakano, X Liu, A Arshi, Y Nakashima… - Nature …, 2013 - nature.com
Haematopoietic cells arise from spatiotemporally restricted domains in the developing
embryo. Although studies of non-mammalian animal and in vitro embryonic stem cell models …
embryo. Although studies of non-mammalian animal and in vitro embryonic stem cell models …
[HTML][HTML] Scl represses cardiomyogenesis in prospective hemogenic endothelium and endocardium
…, A Montel-Hagen, R Sasidharan, H Nakano… - Cell, 2012 - cell.com
Endothelium in embryonic hematopoietic tissues generates hematopoietic stem/progenitor
cells; however, it is unknown how its unique potential is specified. We show that transcription …
cells; however, it is unknown how its unique potential is specified. We show that transcription …
Glucose inhibits cardiac muscle maturation through nucleotide biosynthesis
H Nakano, I Minami, D Braas, H Pappoe, X Wu… - Elife, 2017 - elifesciences.org
10.7554/eLife.29330.001 The heart switches its energy substrate from glucose to fatty acids
at birth, and maternal hyperglycemia is associated with congenital heart disease. However, …
at birth, and maternal hyperglycemia is associated with congenital heart disease. However, …
Mitochondrial Ca2+ uptake by the voltage-dependent anion channel 2 regulates cardiac rhythmicity
10.7554/eLife.04801.001 Tightly regulated Ca 2+ homeostasis is a prerequisite for proper
cardiac function. To dissect the regulatory network of cardiac Ca 2+ handling, we performed a …
cardiac function. To dissect the regulatory network of cardiac Ca 2+ handling, we performed a …
Rigid microenvironments promote cardiac differentiation of mouse and human embryonic stem cells
A Arshi, Y Nakashima, H Nakano… - … and technology of …, 2013 - iopscience.iop.org
While adult heart muscle is the least regenerative of tissues, embryonic cardiomyocytes are
proliferative, with embryonic stem (ES) cells providing an endless reservoir. In addition to …
proliferative, with embryonic stem (ES) cells providing an endless reservoir. In addition to …
[HTML][HTML] GLUT1 overexpression enhances glucose metabolism and promotes neonatal heart regeneration
…, M Pellegrini, H Christofk, H Nakano, A Nakano - Scientific reports, 2021 - nature.com
The mammalian heart switches its main metabolic substrate from glucose to fatty acids
shortly after birth. This metabolic switch coincides with the loss of regenerative capacity in the …
shortly after birth. This metabolic switch coincides with the loss of regenerative capacity in the …
[PDF][PDF] Endocardially derived macrophages are essential for valvular remodeling
…, T Hsiai, A Deb, B Zhou, H Nakano, A Nakano - Developmental cell, 2019 - cell.com
During mammalian embryogenesis, de novo hematopoiesis occurs transiently in multiple
anatomical sites including the yolk sac, dorsal aorta, and heart tube. A long-unanswered …
anatomical sites including the yolk sac, dorsal aorta, and heart tube. A long-unanswered …
[HTML][HTML] Complete atrial-specific knockout of sodium-calcium exchange eliminates sinoatrial node pacemaker activity
The origin of sinoatrial node (SAN) pacemaker activity in the heart is controversial. The leading
candidates are diastolic depolarization by “funny” current (I f ) through HCN4 channels (…
candidates are diastolic depolarization by “funny” current (I f ) through HCN4 channels (…
Flow-induced protein kinase A–CREB pathway acts via BMP signaling to promote HSC emergence
Fluid shear stress promotes the emergence of hematopoietic stem cells (HSCs) in the aorta–gonad–mesonephros
(AGM) of the developing mouse embryo. We determined that the AGM …
(AGM) of the developing mouse embryo. We determined that the AGM …