B-cell antigen receptor (BCR) expression is an important feature of chronic lymphocytic
leukaemia (CLL), one of the most prevalent B-cell neoplasias in Western countries 1 . The …

The pre-B-cell receptor (pre-BCR) is expressed following the productive recombination of the
immunoglobulin heavy chain gene. Signals through the pre-BCR are required for initiating …

SRp20 is a member of the highly conserved SR family of splicing regulators. Using a variety
of reporter gene constructs, we show that SRp20 regulates alternative splicing of its own …

The fatal immune dysregulation that sometimes follows EBV infection in boys has been linked
to mutations in two X chromosome–encoded genes, SLAM-associated protein (SAP) and X…

The B cell antigen receptor (BCR) consists of the membrane-bound immunoglobulin (Ig)
molecule as antigen-binding subunit and the Ig-α/Ig-β heterodimer as signaling subunit. BCR …

During signal transduction through the B cell antigen receptor (BCR), several signaling
elements are brought together by the adaptor protein SLP-65. We have investigated the role of …

The role of the transcription factor Yin Yang 1 (YY1) in development is largely unknown.
Here we show that specific ablation of YY1 in mouse B cells caused a defect in somatic …

The COVID-19 pandemic has resulted in significant morbidity and mortality worldwide. In
order to prevent severe infection, mass COVID-19 vaccination campaigns with several vaccine …

Ikaros DNA-binding proteins are critical for the development of lymphocytes and other
hematopoietic lineages, but it remains unclear how they cooperate with other regulators of …

Tyrosine kinase inhibitors (TKIs) are widely used to treat patients with leukaemia driven by
BCR–ABL1 (ref. 1 ) and other oncogenic tyrosine kinases 2 , 3 . Recent efforts have focused …