We conducted a meta-analysis of Parkinson's disease genome-wide association studies
using a common set of 7,893,274 variants across 13,708 cases and 95,282 controls. Twenty-six …

Parkinson's disease is a common disorder that leads to motor and cognitive disability. We
performed a genome-wide association study of 2,000 individuals with Parkinson's disease (…

Spinocerebellar ataxia type 2 (SCA2) has been recognized recently as an uncommon cause
of parkinsonism, an alternate presentation to the typical cerebellar disorder. This research …

To study the effect of host genetics on gut microbiome composition, the MiBioGen consortium
curated and analyzed genome-wide genotypes and 16S fecal microbiome data from …

Background There is mounting evidence for a connection between the gut and Parkinson's
disease (PD). Dysbiosis of gut microbiota could explain several features of PD. Objective The …

More than 800 published genetic association studies have implicated dozens of potential
risk loci in Parkinson's disease (PD). To facilitate the interpretation of these findings, we have …

Autosomal dominant parkinsonism has been attributed to pathogenic amino acid substitutions
in leucine-rich repeat kinase 2 (LRRK2). By sequencing multiplex families consistent with …

Pallido-ponto-nigral degeneration (PPND) is one of the most well characterized familial
neurodegenerative disorders linked to chromosome 17q21–22. These hereditary disorders are …

Parkinson’s disease (PD) may start in the gut and spread to the brain. To investigate the role
of gut microbiome, we conducted a large-scale study, at high taxonomic resolution, using …

Background Several studies have shown that individually memory, hippocampal volume,
and motor measures presage the onset of dementia. It is unclear if these independently …