Crystal structure of the human σ1 receptor
The human σ 1 receptor is an enigmatic endoplasmic-reticulum-resident transmembrane
protein implicated in a variety of disorders including depression, drug addiction, and …
protein implicated in a variety of disorders including depression, drug addiction, and …
Identification of the gene that codes for the σ2 receptor
The σ 2 receptor is an enigmatic protein that has attracted significant attention because of its
involvement in diseases as diverse as cancer and neurological disorders. Unlike virtually all …
involvement in diseases as diverse as cancer and neurological disorders. Unlike virtually all …
The molecular function of σ receptors: past, present, and future
HR Schmidt, AC Kruse - Trends in pharmacological sciences, 2019 - cell.com
The σ 1 and σ 2 receptors are enigmatic proteins that have attracted attention for decades
due to the chemical diversity and therapeutic potential of their ligands. However, despite …
due to the chemical diversity and therapeutic potential of their ligands. However, despite …
Structural basis for σ1 receptor ligand recognition
The σ 1 receptor is a poorly understood membrane protein expressed throughout the human
body. Ligands targeting the σ 1 receptor are in clinical trials for treatment of Alzheimer’s …
body. Ligands targeting the σ 1 receptor are in clinical trials for treatment of Alzheimer’s …
Molecular mechanisms of olfactory detection in insects: beyond receptors
HR Schmidt, R Benton - Open Biology, 2020 - royalsocietypublishing.org
Insects thrive in diverse ecological niches in large part because of their highly sophisticated
olfactory systems. Over the last two decades, a major focus in the study of insect olfaction …
olfactory systems. Over the last two decades, a major focus in the study of insect olfaction …
Molecular reconstruction of recurrent evolutionary switching in olfactory receptor specificity
LL Prieto-Godino, HR Schmidt, R Benton - Elife, 2021 - elifesciences.org
Olfactory receptor repertoires exhibit remarkable functional diversity, but how these proteins
have evolved is poorly understood. Through analysis of extant and ancestrally reconstructed …
have evolved is poorly understood. Through analysis of extant and ancestrally reconstructed …
Virtual Screening for Ligand Discovery at the σ1 Receptor
DA Greenfield, HR Schmidt, MA Skiba… - ACS Medicinal …, 2020 - ACS Publications
The σ 1 receptor is a transmembrane protein implicated in several pathophysiological
conditions, including neurodegenerative disease ( J. Pharmacol. Sci. 2015 127 1 17 29 ), drug …
conditions, including neurodegenerative disease ( J. Pharmacol. Sci. 2015 127 1 17 29 ), drug …
Investigating isoindoline, tetrahydroisoquinoline, and tetrahydrobenzazepine scaffolds for their sigma receptor binding properties
K Linkens, HR Schmidt, JJ Sahn, AC Kruse… - European Journal of …, 2018 - Elsevier
Substituted norbenzomorphans are known to display high affinity and selectivity for the two
sigma receptor (σR) subtypes. In order to study the effects of simplifying the structures of …
sigma receptor (σR) subtypes. In order to study the effects of simplifying the structures of …
[HTML][HTML] Novel radioligands for imaging sigma-1 receptor in brain using positron emission tomography (PET)
The sigma-1 receptor (σ 1 R) is a unique intracellular protein. σ 1 R plays a major role in
various pathological conditions in the central nervous system (CNS), implicated in several …
various pathological conditions in the central nervous system (CNS), implicated in several …
Quaternary and tertiary aldoxime antidotes for organophosphate exposure in a zebrafish model system
HR Schmidt, Z Radić, P Taylor, EA Fradinger - Toxicology and Applied …, 2015 - Elsevier
The zebrafish is rapidly becoming an important model system for screening of new therapeutics.
Here we evaluated the zebrafish as a potential pharmacological model for screening …
Here we evaluated the zebrafish as a potential pharmacological model for screening …