Generating sufficient antibody to block infection is a key challenge for vaccines against
malaria. Here, we show that antibody titers to a key target, the repeat region of the Plasmodium …

Protective high-affinity antibody responses depend on competitive selection of B cells carrying
somatically mutated B-cell receptors by follicular helper T (T FH ) cells in germinal centres…

Blocking pyrimidine de novo synthesis by inhibiting dihydroorotate dehydrogenase is used
to treat autoimmunity and prevent expansion of rapidly dividing cell populations including …

The repeat region of the Plasmodium falciparum circumsporozoite protein (CSP) is a major
vaccine antigen because it can be targeted by parasite neutralizing antibodies; however, little …

The composition of leukocytes in the liver is highly distinct from that of the blood and
lymphoid organs. In particular, the liver is highly enriched in non‐conventional T cells such as …

Antibodies targeting the NANP/NVDP repeat domain of the Plasmodium falciparum
circumsporozoite protein (CSP Repeat ) can protect against malaria. However, it has also been …

Estimates of seroprevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
antibodies have been hampered by inadequate assay sensitivity and specificity. Using …

Upon encountering cognate antigen, B cells can differentiate into short-lived plasmablasts,
early memory B cells or germinal center B cells. The factors that determine this fate decision …

Liver-resident CD8+ T cells can play critical roles in the control of pathogens, including
Plasmodium and hepatitis B virus. Paradoxically, it has also been proposed that the liver may act …

CD8+ resident memory T (TRM) cells from different tissues form a heterogeneous
population. Transforming growth factor (TGF)-β-independent CD103–TRM cells in the liver …