In Rspondin-based 3D cultures, Lgr5 stem cells from multiple organs form ever-expanding
epithelial organoids that retain their tissue identity. We report the establishment of tumor …

Human liver cancer research currently lacks in vitro models that can faithfully recapitulate
the pathophysiology of the original tumor. We recently described a novel, near-physiological …

We report the derivation of 30 patient-derived organoid lines (PDOs) from tumors arising in
the pancreas and distal bile duct. PDOs recapitulate tumor histology and contain genetic …

Esophageal adenocarcinoma (EAC) incidence is increasing while 5-year survival rates
remain less than 15%. A lack of experimental models has hampered progress. We have …

In vitro cancer cell cultures are facile experimental models used widely for research and drug
development. Many cancer cell lines are available and efforts are ongoing to derive new …

… Hayley E. Francies … Francies is a leader of the Cancer Dependency Map project at the
Wellcome Sanger Institute in Hinxton, UK. …

Drug sensitivity testing utilizing preclinical disease models such as cancer cell lines is an
important and widely used tool for drug development. Importantly, when combined with …

Cellular dormancy and heterogeneity in cell cycle length provide important explanations for
treatment failure after adjuvant therapy with S-phase cytotoxics in colorectal cancer (CRC), …

Organoid cell culture methodologies are enabling the generation of cell models from healthy
and diseased tissue. Patient-derived cancer organoids that recapitulate the genetic and …

Since the approval of trastuzumab for the treatment of breast cancers more than two decades
ago, many clinically effective targeted anti-cancer therapies have been developed. Here …