A single‐cell transcriptome atlas of the adult human retina
…, JS Jabbari, E Welby, JC Sowden, HS Waugh… - The EMBO …, 2019 - embopress.org
The retina is a specialized neural tissue that senses light and initiates image processing.
Although the functional organization of specific retina cells has been well studied, the …
Although the functional organization of specific retina cells has been well studied, the …
Mitochondrial dysfunction in glaucoma and emerging bioenergetic therapies
…, GY Kong, V Chrysostomou, HS Waugh… - Experimental eye …, 2011 - Elsevier
The similarities between glaucoma and mitochondrial optic neuropathies have driven a
growing interest in exploring mitochondrial function in glaucoma. The specific loss of retinal …
growing interest in exploring mitochondrial function in glaucoma. The specific loss of retinal …
[HTML][HTML] Amyloid precursor protein drives down-regulation of mitochondrial oxidative phosphorylation independent of amyloid beta
MIG Lopez Sanchez, HS Waugh, A Tsatsanis… - Scientific reports, 2017 - nature.com
Amyloid precursor protein (APP) and its extracellular domain, soluble APP alpha (sAPPα)
play important physiological and neuroprotective roles. However, rare forms of familial …
play important physiological and neuroprotective roles. However, rare forms of familial …
Defined medium conditions for the induction and expansion of human pluripotent stem cell-derived retinal pigment epithelium
…, D Hernández, J Kie, A Conquest, HS Waugh… - Stem cell reviews and …, 2016 - Springer
We demonstrate that a combination of Noggin, Dickkopf-1, Insulin Growth Factor 1 and basic
Fibroblast Growth Factor, promotes the differentiation of human pluripotent stem cells into …
Fibroblast Growth Factor, promotes the differentiation of human pluripotent stem cells into …
[HTML][HTML] Amyloid precursor protein mediates neuronal protection from rotenone toxicity
K Cimdins, HS Waugh, V Chrysostomou… - Molecular …, 2019 - Springer
Mitochondrial complex I dysfunction is the most common respiratory chain defect in human
disorders and a hotspot for neurodegenerative diseases. Amyloid precursor protein (APP) …
disorders and a hotspot for neurodegenerative diseases. Amyloid precursor protein (APP) …
Generation of human neural retina transcriptome atlas by single cell RNA sequencing
…, JS Jabbari, E Welby, JC Sowden, HS Waugh… - bioRxiv, 2018 - biorxiv.org
The retina is a highly specialized neural tissue that senses light and initiates image processing.
Although the functional organisation of specific cells within the retina has been well-…
Although the functional organisation of specific cells within the retina has been well-…
Correction to: Amyloid Precursor Protein Mediates Neuronal Protection from Rotenone Toxicity
K Cimdins, HS Waugh, V Chrysostomou… - Molecular …, 2019 - ncbi.nlm.nih.gov
… Kathryn Cimdins, 1, 2 Hayley S. Waugh, 1, 2 Vicki Chrysostomou, 1, 2 M. Isabel G. Lopez
Sanchez, 1, 2 Vanessa A. … Publisher’s Note …
Sanchez, 1, 2 Vanessa A. … Publisher’s Note …
Amyloid Precursor Protein-mediated Neuroprotection In The Aged Retina
HS Waugh, K Cimdins, IA Trounce… - … & Visual Science, 2011 - tvst.arvojournals.org
Purpose: Increasing age is a major risk factor for neuronal loss in Alzheimer’s disease and
retinal ganglion cell (RGC) loss in glaucoma. Oxidative stress associated with aging …
retinal ganglion cell (RGC) loss in glaucoma. Oxidative stress associated with aging …
Amyloid precursor protein protects against a rodent model of optic neuropathy and is abundant in the human vitreous
H Waugh, V Chrysostomou… - … & Visual Science, 2014 - iovs.arvojournals.org
Purpose: Age is a major risk factor for both Alzheimer’s disease (AD) and glaucoma. There
is evidence of increased rates of glaucoma in AD patients. AD pathology includes …
is evidence of increased rates of glaucoma in AD patients. AD pathology includes …
Fasting-induced adipose factor identified as a key adipokine that is up-regulated in white adipose tissue during pregnancy and lactation in the rat
Adipokines, which are expressed and secreted from white adipose tissue (WAT), are
potential factors that could contribute to the changes in energy homeostasis that occurs in …
potential factors that could contribute to the changes in energy homeostasis that occurs in …