A single‐cell transcriptome atlas of the adult human retina

…, JS Jabbari, E Welby, JC Sowden, HS Waugh… - The EMBO …, 2019 - embopress.org
The retina is a specialized neural tissue that senses light and initiates image processing.
Although the functional organization of specific retina cells has been well studied, the …

Mitochondrial dysfunction in glaucoma and emerging bioenergetic therapies

…, GY Kong, V Chrysostomou, HS Waugh… - Experimental eye …, 2011 - Elsevier
The similarities between glaucoma and mitochondrial optic neuropathies have driven a
growing interest in exploring mitochondrial function in glaucoma. The specific loss of retinal …

[HTML][HTML] Amyloid precursor protein drives down-regulation of mitochondrial oxidative phosphorylation independent of amyloid beta

MIG Lopez Sanchez, HS Waugh, A Tsatsanis… - Scientific reports, 2017 - nature.com
Amyloid precursor protein (APP) and its extracellular domain, soluble APP alpha (sAPPα)
play important physiological and neuroprotective roles. However, rare forms of familial …

Defined medium conditions for the induction and expansion of human pluripotent stem cell-derived retinal pigment epithelium

…, D Hernández, J Kie, A Conquest, HS Waugh… - Stem cell reviews and …, 2016 - Springer
We demonstrate that a combination of Noggin, Dickkopf-1, Insulin Growth Factor 1 and basic
Fibroblast Growth Factor, promotes the differentiation of human pluripotent stem cells into …

[HTML][HTML] Amyloid precursor protein mediates neuronal protection from rotenone toxicity

K Cimdins, HS Waugh, V Chrysostomou… - Molecular …, 2019 - Springer
Mitochondrial complex I dysfunction is the most common respiratory chain defect in human
disorders and a hotspot for neurodegenerative diseases. Amyloid precursor protein (APP) …

Generation of human neural retina transcriptome atlas by single cell RNA sequencing

…, JS Jabbari, E Welby, JC Sowden, HS Waugh… - bioRxiv, 2018 - biorxiv.org
The retina is a highly specialized neural tissue that senses light and initiates image processing.
Although the functional organisation of specific cells within the retina has been well-…

Correction to: Amyloid Precursor Protein Mediates Neuronal Protection from Rotenone Toxicity

K Cimdins, HS Waugh, V Chrysostomou… - Molecular …, 2019 - ncbi.nlm.nih.gov
… Kathryn Cimdins, 1, 2 Hayley S. Waugh, 1, 2 Vicki Chrysostomou, 1, 2 M. Isabel G. Lopez
Sanchez, 1, 2 Vanessa A. … Publisher’s Note …

Amyloid Precursor Protein-mediated Neuroprotection In The Aged Retina

HS Waugh, K Cimdins, IA Trounce… - … & Visual Science, 2011 - tvst.arvojournals.org
Purpose: Increasing age is a major risk factor for neuronal loss in Alzheimer’s disease and
retinal ganglion cell (RGC) loss in glaucoma. Oxidative stress associated with aging …

Amyloid precursor protein protects against a rodent model of optic neuropathy and is abundant in the human vitreous

H Waugh, V Chrysostomou… - … & Visual Science, 2014 - iovs.arvojournals.org
Purpose: Age is a major risk factor for both Alzheimer’s disease (AD) and glaucoma. There
is evidence of increased rates of glaucoma in AD patients. AD pathology includes …

Fasting-induced adipose factor identified as a key adipokine that is up-regulated in white adipose tissue during pregnancy and lactation in the rat

T Josephs, H Waugh, I Kokay, D Grattan… - Journal of …, 2007 - joe.bioscientifica.com
Adipokines, which are expressed and secreted from white adipose tissue (WAT), are
potential factors that could contribute to the changes in energy homeostasis that occurs in …