Background The mouse inbred line C57BL/6J is widely used in mouse genetics and its
genome has been incorporated into many genetic reference populations. More recently large …

Traumatic brain injury (TBI) is caused by brain deformations resulting in the pathophysiological
activation of cellular cascades which produce delayed cell damage and death. …

Traumatic brain injury (TBI) is caused by rapid deformation of the brain, resulting in a
cascade of pathological events and ultimately neurodegeneration. Understanding how the …

An important factor in reducing variability in mouse test outcomes has been to develop assays
that can be used for continuous automated home cage assessment. Our experience has …

Deformation of brain tissue in response to mechanical loading of the head is the root-cause
of traumatic brain injury (TBI). Even below ultimate failure limits, deformation activates …

The function of the majority of genes in the mouse and human genomes remains unknown.
The mouse embryonic stem cell knockout resource provides a basis for the characterization …

The developmental and physiological complexity of the auditory system is likely reflected in
the underlying set of genes involved in auditory function. In humans, over 150 non-…

Central nervous system disorders such as autism as well as the range of neurodegenerative
diseases such as Huntington's disease are commonly investigated using genetically altered …

The identification of causal variants in sequencing studies remains a considerable challenge
that can be partially addressed by new gene-specific knowledge. Here, we integrate …

Clinical presentation of congenital heart disease is heterogeneous, making identification of
the disease-causing genes and their genetic pathways and mechanisms of action …