User profiles for Heather Christofk
Heather ChristofkAssociate Professor of Molecular and Medical Pharmacology and Biological Chemistry … Verified email at mednet.ucla.edu Cited by 13955 |
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
HR Christofk, MG Vander Heiden, MH Harris… - Nature, 2008 - nature.com
Many tumour cells have elevated rates of glucose uptake but reduced rates of oxidative
phosphorylation. This persistence of high lactate production by tumours in the presence of …
phosphorylation. This persistence of high lactate production by tumours in the presence of …
Pyruvate kinase M2 is a phosphotyrosine-binding protein
HR Christofk, MG Vander Heiden, N Wu, JM Asara… - Nature, 2008 - nature.com
Growth factors stimulate cells to take up excess nutrients and to use them for anabolic processes.
The biochemical mechanism by which this is accomplished is not fully understood but …
The biochemical mechanism by which this is accomplished is not fully understood but …
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis
…, KE Yen, K Kunii, SM Davidson, HR Christofk… - Nature chemical …, 2012 - nature.com
Cancer cells engage in a metabolic program to enhance biosynthesis and support cell
proliferation. The regulatory properties of pyruvate kinase M2 (PKM2) influence altered glucose …
proliferation. The regulatory properties of pyruvate kinase M2 (PKM2) influence altered glucose …
Evidence for an alternative glycolytic pathway in rapidly proliferating cells
…, H Sharfi, GJ Heffron, D Amador-Noguez, HR Christofk… - Science, 2010 - science.org
Proliferating cells, including cancer cells, require altered metabolism to efficiently
incorporate nutrients such as glucose into biomass. The M2 isoform of pyruvate kinase (PKM2) …
incorporate nutrients such as glucose into biomass. The M2 isoform of pyruvate kinase (PKM2) …
The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR
Metabolism and ageing are intimately linked. Compared with ad libitum feeding, dietary
restriction consistently extends lifespan and delays age-related diseases in evolutionarily …
restriction consistently extends lifespan and delays age-related diseases in evolutionarily …
Metabolic state of glioma stem cells and nontumorigenic cells
…, C Dekmezian, K Reue, H Christofk… - Proceedings of the …, 2011 - National Acad Sciences
Gliomas contain a small number of treatment-resistant glioma stem cells (GSCs), and it is
thought that tumor regrowth originates from GSCs, thus rendering GSCs an attractive target for …
thought that tumor regrowth originates from GSCs, thus rendering GSCs an attractive target for …
[HTML][HTML] Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor
Cellular amino acid uptake is critical for mTOR complex 1 (mTORC1) activation and cell
proliferation. However, the regulation of amino acid uptake is not well-understood. Here we …
proliferation. However, the regulation of amino acid uptake is not well-understood. Here we …
New aspects of the Warburg effect in cancer cell biology
SJ Bensinger, HR Christofk - Seminars in cell & developmental biology, 2012 - Elsevier
Altered cellular metabolism is a defining feature of cancer [1]. The best studied metabolic
phenotype of cancer is aerobic glycloysis – also known as the Warburg effect – characterized …
phenotype of cancer is aerobic glycloysis – also known as the Warburg effect – characterized …
[HTML][HTML] Viral hijacking of cellular metabolism
This review discusses the current state of the viral metabolism field and gaps in knowledge
that will be important for future studies to investigate. We discuss metabolic rewiring caused …
that will be important for future studies to investigate. We discuss metabolic rewiring caused …
Identification of small molecule inhibitors of pyruvate kinase M2
MG Vander Heiden, HR Christofk, E Schuman… - Biochemical …, 2010 - Elsevier
A common feature of tumors arising from diverse tissue types is a reliance on aerobic glycolysis
for glucose metabolism. This metabolic difference between cancer cells and normal cells …
for glucose metabolism. This metabolic difference between cancer cells and normal cells …