The biology of IGE and the basis of allergic disease
…, RL Beavil, N McCloskey, HA Coker… - Annual review of …, 2003 - annualreviews.org
Allergic individuals exposed to minute quantities of allergen experience an immediate
response. Immediate hypersensitivity reflects the permanent sensitization of mucosal mast cells …
response. Immediate hypersensitivity reflects the permanent sensitization of mucosal mast cells …
[HTML][HTML] Activation-induced cytidine deaminase deaminates 5-methylcytosine in DNA and is expressed in pluripotent tissues: implications for epigenetic …
DNA deaminases of the Aid/Apobec family convert cytosine into uracil and play key roles in
acquired and innate immunity. The epigenetic modification by methylation of cytosine in CpG …
acquired and innate immunity. The epigenetic modification by methylation of cytosine in CpG …
Allergen drives class switching to IgE in the nasal mucosa in allergic rhinitis
P Takhar, L Smurthwaite, HA Coker… - The Journal of …, 2005 - journals.aai.org
IgE-expressing B cells are over 1000 times more frequent in the nasal B cell than the
peripheral blood B cell population. We have investigated the provenance of these B cells in the …
peripheral blood B cell population. We have investigated the provenance of these B cells in the …
[PDF][PDF] A pooled shRNA screen identifies Rbm15, Spen, and Wtap as factors required for Xist RNA-mediated silencing
X-chromosome inactivation is the process that evolved in mammals to equalize levels of X-linked
gene expression in XX females relative to XY males. Silencing of a single X …
gene expression in XX females relative to XY males. Silencing of a single X …
[PDF][PDF] Smchd1-dependent and-independent pathways determine developmental dynamics of CpG island methylation on the inactive X chromosome
AV Gendrel, A Apedaile, H Coker, A Termanis… - Developmental cell, 2012 - cell.com
X chromosome inactivation involves multiple levels of chromatin modification, established
progressively and in a stepwise manner during early development. The chromosomal protein …
progressively and in a stepwise manner during early development. The chromosomal protein …
Local somatic hypermutation and class switch recombination in the nasal mucosa of allergic rhinitis patients
HA Coker, SR Durham, HJ Gould - The Journal of Immunology, 2003 - journals.aai.org
Immunoglobulin E is produced by nasal B cells in response to allergen. We have analyzed
IgE VH region sequences expressed in the nasal mucosa of patients suffering from allergic …
IgE VH region sequences expressed in the nasal mucosa of patients suffering from allergic …
m6A modification of non-coding RNA and the control of mammalian gene expression
H Coker, G Wei, N Brockdorff - Biochimica et Biophysica Acta (BBA)-Gene …, 2019 - Elsevier
The biology of non-coding RNA (ncRNA) and the regulation of mammalian gene expression
is a rapidly expanding field. In this review, we consider how recent advances in technology, …
is a rapidly expanding field. In this review, we consider how recent advances in technology, …
The nuclear matrix protein CIZ1 facilitates localization of Xist RNA to the inactive X-chromosome territory
…, ER Stewart, TB Nesterova, H Coker… - Genes & …, 2017 - genesdev.cshlp.org
The nuclear matrix protein Cip1-interacting zinc finger protein 1 (CIZ1) promotes DNA replication
in association with cyclins and has been linked to adult and pediatric cancers. Here we …
in association with cyclins and has been linked to adult and pediatric cancers. Here we …
[HTML][HTML] Systematic allelic analysis defines the interplay of key pathways in X chromosome inactivation
Xist RNA, the master regulator of X chromosome inactivation, acts in cis to induce
chromosome-wide silencing. Whilst recent studies have defined candidate silencing factors, their …
chromosome-wide silencing. Whilst recent studies have defined candidate silencing factors, their …
Acute depletion of METTL3 implicates N6-methyladenosine in alternative intron/exon inclusion in the nascent transcriptome
RNA N 6 -methyladenosine (m 6 A) modification plays important roles in multiple aspects of
RNA regulation. m 6 A is installed cotranscriptionally by the METTL3/14 complex, but its …
RNA regulation. m 6 A is installed cotranscriptionally by the METTL3/14 complex, but its …