We established a collection of 7,000 transgenic lines of Drosophila melanogaster. Expression
of GAL4 in each line is controlled by a different, defined fragment of genomic DNA that …

10.7554/eLife.04577.001 We identified the neurons comprising the Drosophila mushroom
body (MB), an associative center in invertebrate brains, and provide a comprehensive map …

Serotonin (5-HT) modulates synaptic efficacy in the nervous system of vertebrates and
invertebrates. In the nematode Caenorhabditis elegans, many behaviors are regulated by 5-HT …

The ability to reproducibly target expression of transgenes to small, defined subsets of cells
is a key experimental tool for understanding many biological processes. The Drosophila …

Notch signaling is critical for cell fate decisions during development. Caenorhabditis elegans
and vertebrate Notch ligands are more diverse than classical Drosophila Notch ligands, …

Cell polarity and cell proliferation can be coupled in animal tissues, but how they are coupled
is not understood. In Drosophila imaginal discs, loss of the neoplastic tumor suppressor …

10.7554/eLife.43079.001 Animals exhibit innate behaviours to a variety of sensory stimuli
including olfactory cues. In Drosophila, one higher olfactory centre, the lateral horn (LH), is …

Background The conserved DOS-motif proteins OSM-7 and OSM-11 function as coligands
with canonical DSL (Delta, Serrate, and LAG-2) ligands to activate C. elegans Notch …

Signaling mucins are cell adhesion molecules that activate RAS/RHO guanosine triphosphatases
and their effector mitogen-activated protein kinase (MAPK) pathways. We found that …

The small GTPase Rab5 has emerged as an important regulator of animal development, and
it is essential for endocytic trafficking. However, the mechanisms that link Rab5 activation to …