Rejection of immunogenic tumor clones is limited by clonal fraction
10.7554/eLife.41090.001 Tumors often co-exist with T cells that recognize somatically
mutated peptides presented by cancer cells on major histocompatibility complex I (MHC-I). …
mutated peptides presented by cancer cells on major histocompatibility complex I (MHC-I). …
[HTML][HTML] Empirical and rational design of T cell receptor-based immunotherapies
The use of T cells reactive with intracellular tumor-associated or tumor-specific antigens has
been a promising strategy for cancer immunotherapies in the past three decades, but the …
been a promising strategy for cancer immunotherapies in the past three decades, but the …
Identification of the targets of T-cell receptor therapeutic agents and cells by use of a high-throughput genetic platform
… E and F, Heatmaps of the single amino acid substituted peptides obtained in the A6 (four
replicates) and B7 (three replicates) minigene depletion assay experiments, respectively. Black …
replicates) and B7 (three replicates) minigene depletion assay experiments, respectively. Black …
An input-controlled model system for identification of MHC bound peptides enabling laboratory comparisons of immunopeptidome experiments
Abstract Characterization of MHC-bound peptides by mass spectrometry (MS) is an essential
technique for immunologic studies. Many efforts have been made to quantify the number of …
technique for immunologic studies. Many efforts have been made to quantify the number of …
Direct substitution of arylalkynyl carbinols provides access to diverse terminal acetylene building blocks
…, EW Scocchera, S Keshipeddy, HF Jones… - Organic …, 2017 - ACS Publications
To develop next generation antifolates for the treatment of trimethoprim-resistant bacteria,
synthetic methods were needed to prepare a diverse array of 3-aryl-propynes with various …
synthetic methods were needed to prepare a diverse array of 3-aryl-propynes with various …
Prospective identification of cross-reactive human peptide-MHC ligands for T cell receptor based therapies
T cell receptor (TCR)-based therapeutic cells and agents (eg adoptive T cell 1 , 2 , TCR-engineered
T cells 3 , ImmTACs 4 , TCR mimic antibodies 5 , neoantigen vaccines 6 , 7 ) have …
T cells 3 , ImmTACs 4 , TCR mimic antibodies 5 , neoantigen vaccines 6 , 7 ) have …
Continent-wide declines in shallow reef life over a decade of ocean warming
Human society is dependent on nature 1 , 2 , but whether our ecological foundations are at
risk remains unknown in the absence of systematic monitoring of species’ populations 3 . …
risk remains unknown in the absence of systematic monitoring of species’ populations 3 . …
[HTML][HTML] Overcome imposter syndrome: Contribute to working groups and build strong networks
Scientific working groups bring together experts from different disciplines and perspectives
to tackle the “wicked problems” facing natural systems and society. Yet participants can feel …
to tackle the “wicked problems” facing natural systems and society. Yet participants can feel …
Taxonomic composition of mobile epifaunal invertebrate assemblages on diverse benthic microhabitats from temperate to tropical reefs
Anthropogenic drivers are flattening reef structure from 3-dimensional habitats composed of
macroalgae and live branching corals towards low-profile turfing algae. Our current …
macroalgae and live branching corals towards low-profile turfing algae. Our current …
Using eDNA and SCUBA surveys for detection and monitoring of a threatened marine cryptic fish
Quantification of species’ spatial distributions and population trends is crucial for successful
conservation efforts. Obtaining sufficient population data, however, is often difficult in the …
conservation efforts. Obtaining sufficient population data, however, is often difficult in the …