[HTML][HTML] A SARS-CoV-2 spike ferritin nanoparticle vaccine protects hamsters against Alpha and Beta virus variant challenge
…, M Zemil, A Anderson, J Darden, H Hernandez… - npj Vaccines, 2021 - nature.com
The emergence of SARS-CoV-2 variants of concern (VOC) requires adequate coverage of
vaccine protection. We evaluated whether a SARS-CoV-2 spike ferritin nanoparticle vaccine (…
vaccine protection. We evaluated whether a SARS-CoV-2 spike ferritin nanoparticle vaccine (…
Characterization of the Cofactor Composition of Escherichia coli Biotin Synthase
MM Cosper, GNL Jameson, HL Hernández… - Biochemistry, 2004 - ACS Publications
The cofactor content of in vivo, as-isolated, and reconstituted forms of recombinant
Escherichia coli biotin synthase (BioB) has been investigated using the combination of UV−visible …
Escherichia coli biotin synthase (BioB) has been investigated using the combination of UV−visible …
[HTML][HTML] Characterization of MOCS1A, an oxygen-sensitive iron-sulfur protein involved in human molybdenum cofactor biosynthesis
P Hänzelmann, HL Hernández, C Menzel… - Journal of Biological …, 2004 - ASBMB
The human proteins MOCS1A and MOCS1B catalyze the conversion of a guanosine derivative
to precursor Z during molybdenum cofactor biosynthesis. MOCS1A shares homology …
to precursor Z during molybdenum cofactor biosynthesis. MOCS1A shares homology …
MiaB, a Bifunctional Radical-S-Adenosylmethionine Enzyme Involved in the Thiolation and Methylation of tRNA, Contains Two Essential [4Fe-4S] Clusters
HL Hernández, F Pierrel, E Elleingand… - Biochemistry, 2007 - ACS Publications
The radical-S-adenosylmethionine (radical-AdoMet) enzyme MiaB catalyzes the
posttranscriptional methylthiolation of N-6-isopentenyladenosine in tRNAs. Spectroscopic and …
posttranscriptional methylthiolation of N-6-isopentenyladenosine in tRNAs. Spectroscopic and …
ENDOR Spectroscopy Shows That Guanine N1 Binds to [4Fe−4S] Cluster II of the S-Adenosylmethionine-Dependent Enzyme MoaA: Mechanistic Implications
NS Lees, P Hänzelmann, HL Hernandez… - Journal of the …, 2009 - ACS Publications
The S-adenosylmethionine-dependent enzyme MoaA, in concert with MoaC, catalyzes the
first step of molybdenum cofactor biosynthesis, the conversion of guanosine 5′-triphosphate …
first step of molybdenum cofactor biosynthesis, the conversion of guanosine 5′-triphosphate …
[HTML][HTML] MiaB protein from Thermotoga maritima: Characterization of an extremely thermophilic tRNA-methylthiotransferase
F Pierrel, HL Hernandez, MK Johnson… - Journal of Biological …, 2003 - ASBMB
In Escherichia coli, the MiaB protein catalyzes the methylthiolation of N-6-isopentenyl
adenosine in tRNAs, the last reaction step during biosynthesis of 2-methylthio-N-6-isopentenyl …
adenosine in tRNAs, the last reaction step during biosynthesis of 2-methylthio-N-6-isopentenyl …
Role of the [2Fe−2S] Cluster in Recombinant Escherichia coli Biotin Synthase
GNL Jameson, MM Cosper, HL Hernández… - Biochemistry, 2004 - ACS Publications
Biotin synthase (BioB) converts dethiobiotin into biotin by inserting a sulfur atom between
C6 and C9 of dethiobiotin in an S-adenosylmethionine (SAM)-dependent reaction. The as-…
C6 and C9 of dethiobiotin in an S-adenosylmethionine (SAM)-dependent reaction. The as-…
[HTML][HTML] Possible direct involvement of the active-site [4Fe–4S] cluster of the GcpE enzyme from Thermus thermophilus in the conversion of MEcPP
D Adedeji, H Hernandez, J Wiesner, U Köhler… - FEBS letters, 2007 - Elsevier
The GcpE enzyme converts 2-C-methyl-d-erythritol-2,4-cyclodiphosphate (MEcPP) into (E)-4-hydroxy-3-methyl-but-2-enyl
diphosphate (HMBPP) in the penultimate step of the DOXP …
diphosphate (HMBPP) in the penultimate step of the DOXP …
An EPR/HYSCORE, Mössbauer, and resonance Raman study of the hydrogenase maturation enzyme HydF: a model for N-coordination to [4Fe–4S] clusters
…, M Atta, JM Latour, HL Hernández… - JBIC Journal of …, 2014 - Springer
The biosynthesis of the organometallic H cluster of [Fe–Fe] hydrogenase requires three
accessory proteins, two of which (HydE and HydG) belong to the radical S-adenosylmethionine …
accessory proteins, two of which (HydE and HydG) belong to the radical S-adenosylmethionine …
FG-3019, a human monoclonal antibody to connective tissue growth factor (CTGF), with gemcitabine/erlotinib (G/E) in patients with locally advanced or metastatic …
…, PJ O'Dwyer, K Modelska, M Carney, H Hernandez… - 2014 - ascopubs.org
4138 Background: CTGF is overexpressed in PDAC and facilitates local desmoplasia, tumor
survival and metastasis. FG-3019 is a CTGF-specific monoclonal antibody that decreases …
survival and metastasis. FG-3019 is a CTGF-specific monoclonal antibody that decreases …