We report a single-cell bisulfite sequencing (scBS-seq) method that can be used to accurately
measure DNA methylation at up to 48.4% of CpG sites. Embryonic stem cells grown in …

We report scM&T-seq, a method for parallel single-cell genome-wide methylome and
transcriptome sequencing that allows for the discovery of associations between transcriptional and …

Breast cancer is one of the most common cancers in humans and will on average affect up
to one in eight women in their lifetime in the United States and Europe 1 . The Women’s …

Parallel single-cell sequencing protocols represent powerful methods for investigating regulatory
relationships, including epigenome-transcriptome interactions. Here, we report a single…

Recent technological advances have enabled DNA methylation to be assayed at single-cell
resolution. However, current protocols are limited by incomplete CpG coverage and hence …

Genome-wide erasure of DNA methylation takes place in primordial germ cells (PGCs) and
early embryos and is linked with pluripotency. Inhibition of Erk1/2 and Gsk3β signaling in …

The inheritance of epigenetic marks, in particular DNA methylation, provides a molecular
memory that ensures faithful commitment to transcriptional programs during mammalian …

A decreased hamstring: quadriceps (H: Q) ratio may put the hamstrings and anterior cruciate
ligament (ACL) at increased risk of injury. Therefore, the purpose of this study was to …

Emerging single-cell epigenomic methods are being developed with the exciting potential
to transform our knowledge of gene regulation. Here we review available techniques and …

Mouse embryonic stem (ES) cells are locked into self-renewal by shielding from inductive
cues. Release from this ground state in minimal conditions offers a system for delineating …