αβ and γδ T cells originate from a common, multipotential precursor population in the thymus,
but the molecular mechanisms regulating this lineage-fate decision are unknown. We have …

Age-related macular degeneration is a prevalent neuroinflammatory condition and a major
cause of blindness driven by genetic and environmental factors such as obesity. In diseases …

The recognition by the T cell receptor (TCR) of self-peptides presented by the major
histocompatibility complex (MHC) on antigen-presenting cells, such as dendritic cells and thymic …

Lineage-committed αβ and γδ T cells are thought to originate from common intrathymic
multipotent progenitors following instructive T cell receptor (TCR) signals. A subset of lymph node …

The catalytic activity of Zap70 is crucial for T cell antigen receptor (TCR) signaling, but the
quantitative and temporal requirements for its function in thymocyte development are not …

Positive selection of CD8 T cells in the thymus is thought to be a multistep process lasting 3–4
d; however, the discrete steps involved are poorly understood. Here, we examine …

Humanized mice represent an important model to study the development and function of the
human immune system. While it is known that mouse thymic stromal cells can support …

There is a long-standing assumption that naive CD4 + and CD8 + T cells are largely homogeneous
populations despite the extraordinary diversity of their T cell receptors (TCR). The self…

The ordered migration of thymocytes from the cortex to the medulla is critical for the appropriate
selection of the mature T cell repertoire. Most studies of thymocyte migration rely on …

CD4 + T cells have a remarkable potential to differentiate into diverse effector lineages following
activation. Here, we probe the heterogeneity present among naive CD4 + T cells before …