Specific role of mitochondrial electron transport in blood-stage Plasmodium falciparum

HJ Painter, JM Morrisey, MW Mather, AB Vaidya - nature, 2007 - nature.com
The origin of all mitochondria can be traced to the symbiotic arrangement that resulted in the
emergence of eukaryotes in a world that was exclusively populated by prokaryotes 1 , 2 , 3 . …

The Apicomplexan AP2 family: integral factors regulating Plasmodium development

HJ Painter, TL Campbell, M Llinás - Molecular and biochemical …, 2011 - Elsevier
Malaria is caused by protozoan parasites of the genus Plasmodium and involves infection of
multiple hosts and cell types during the course of an infection. To complete its complex life …

Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics

…, E Owen, M Abraham, G LaMonte, HJ Painter… - Science, 2018 - science.org
Chemogenetic characterization through in vitro evolution combined with whole-genome
analysis can identify antimalarial drug targets and drug-resistance genes. We performed a …

[PDF][PDF] Genetic investigation of tricarboxylic acid metabolism during the Plasmodium falciparum life cycle

…, JM Morrisey, KJ McLean, SM Ganesan, HJ Painter… - Cell reports, 2015 - cell.com
New antimalarial drugs are urgently needed to control drug-resistant forms of the malaria
parasite Plasmodium falciparum. Mitochondrial electron transport is the target of both existing …

[HTML][HTML] Dissecting the role of PfAP2-G in malaria gametocytogenesis

…, J Venezia, L Orchard, R van Biljon, HJ Painter… - Nature …, 2020 - nature.com
In the malaria parasite Plasmodium falciparum, the switch from asexual multiplication to
sexual differentiation into gametocytes is essential for transmission to mosquitos. The …

Metabolomic profiling of the malaria box reveals antimalarial target pathways

EL Allman, HJ Painter, J Samra… - Antimicrobial agents …, 2016 - Am Soc Microbiol
The threat of widespread drug resistance to frontline antimalarials has renewed the urgency
for identifying inexpensive chemotherapeutic compounds that are effective against …

Yeast dihydroorotate dehydrogenase as a new selectable marker for Plasmodium falciparum transfection

SM Ganesan, JM Morrisey, H Ke, HJ Painter… - Molecular and …, 2011 - Elsevier
Genetic manipulation of Plasmodium falciparum in culture through transfection has provided
numerous insights into the molecular and cell biology of this parasite. The procedure is …

[HTML][HTML] Mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, enlarge the parasite's food vacuole and alter drug sensitivities

…, MJ Hoke, LM Altenhofen, HJ Painter, J Mu… - Scientific reports, 2015 - nature.com
Mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, are the
major determinant of chloroquine resistance in this lethal human malaria parasite. Here, we …

[HTML][HTML] Genome-wide real-time in vivo transcriptional dynamics during Plasmodium falciparum blood-stage development

HJ Painter, NC Chung, A Sebastian, I Albert… - Nature …, 2018 - nature.com
Genome-wide analysis of transcription in the malaria parasite Plasmodium falciparum has
revealed robust variation in steady-state mRNA abundance throughout the 48-h …

[HTML][HTML] Hierarchical transcriptional control regulates Plasmodium falciparum sexual differentiation

…, HJ Painter, L Orchard, J Reader, J Niemand… - BMC genomics, 2019 - Springer
Background Malaria pathogenesis relies on sexual gametocyte forms of the malaria parasite
to be transmitted between the infected human and the mosquito host but the molecular …