Nested Russian Doll-Like Genetic Mobility Drives Rapid Dissemination of the Carbapenem Resistance Gene blaKPC

…, A Vaughan, CJ Grim, HL Cox… - Antimicrobial agents …, 2016 - Am Soc Microbiol
The recent widespread emergence of carbapenem resistance in Enterobacteriaceae is a
major public health concern, as carbapenems are a therapy of last resort against this family of …

Molecular dissection of an outbreak of carbapenem-resistant Enterobacteriaceae reveals intergenus KPC carbapenemase transmission through a promiscuous …

AJ Mathers, HL Cox, B Kitchel, H Bonatti… - MBio, 2011 - Am Soc Microbiol
Carbapenem-resistant Enterobacteriaceae (CRE) have emerged as major causes of health
care-associated infections worldwide. This diverse collection of organisms with various …

Unique aspects of antimicrobial use in older adults

CM Faulkner, HL Cox… - Clinical infectious …, 2005 - academic.oup.com
Elderly persons consume a significant proportion of health care resources. Antimicrobials are
just one class among many pharmaceuticals that are prescribed more frequently to elderly …

First clinical cases of OXA-48-producing carbapenem-resistant Klebsiella pneumoniae in the United States: the “menace” arrives in the new world

…, KC Hazen, J Carroll, AJ Yeh, HL Cox… - Journal of clinical …, 2013 - Am Soc Microbiol
OXA-48 has emerged as a major carbapenemase associated with the Enterobacteriaceae
in Europe, North Africa, and Asia. We report the first two clinical cases of OXA-48-type …

Control of simultaneous outbreaks of carbapenemase-producing enterobacteriaceae and extensively drug-resistant Acinetobacter baumannii infection in an intensive …

…, DM Toney, G Slitt, HJ Zapata, HL Cox… - Infection Control & …, 2014 - cambridge.org
ObjectiveWe describe the efficacy of enhanced infection control measures, including those
recommended in the Centers for Disease Control and Prevention’s 2012 carbapenem-…

Reduced Clostridium difficile tests and laboratory-identified events with a computerized clinical decision support tool and financial incentive

GR Madden, IG Mesner, HL Cox… - infection control & …, 2018 - cambridge.org
We hypothesized that a computerized clinical decision support tool for Clostridium difficile
testing would reduce unnecessary inpatient tests, resulting in fewer laboratory-identified …

Fatal cross infection by carbapenem‐resistant Klebsiella in two liver transplant recipients

AJ Mathers, HL Cox, H Bonatti, B Kitchel… - Transplant Infectious …, 2009 - Wiley Online Library
Members of the family Enterobacteriaceae including Klebsiella have re‐emerged as major
pathogens in solid organ transplantation. The recent appearance and dissemination of …

Bacterial community-acquired pneumonia in older patients

GR Donowitz, HL Cox - Clinics in geriatric medicine, 2007 - Elsevier
Pneumonia in the elderly remains a major source of morbidity and mortality in an age group
that is growing in numbers. It remains unclear whether the propensity of older adults to …

The Role of fosA in Challenges with Fosfomycin Susceptibility Testing of Multispecies Klebsiella pneumoniae Carbapenemase-Producing Clinical Isolates

ZS Elliott, KE Barry, HL Cox, N Stoesser… - Journal of clinical …, 2019 - Am Soc Microbiol
With multidrug-resistant (MDR) Enterobacterales on the rise, a nontoxic antimicrobial agent
with a unique mechanism of action such as fosfomycin seems attractive. However, …

Implementation of a rapid phenotypic susceptibility platform for gram-negative bloodstream infections with paired antimicrobial stewardship intervention: is the juice …

…, ZS Elliott, M Poulter, F Brewster, HL Cox… - Clinical Infectious …, 2021 - academic.oup.com
Background Implementation of the Accelerate Pheno TM Gram-negative platform (RDT)
paired with antimicrobial stewardship program (ASP) intervention projects to improve time to …