Plasma concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density
lipoprotein cholesterol and triglycerides are among the most important risk factors for …

Background The incidence of hematologic cancers increases with age. These cancers are
associated with recurrent somatic mutations in specific genes. We hypothesized that such …

Identifying the genetic variants that increase the risk of type 2 diabetes (T2D) in humans has
been a formidable challenge. Adopting a genome-wide association strategy, we genotyped …

Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain
largely elusive. To identify genetic loci for obesity susceptibility, we examined associations …

Levels of circulating glucose are tightly regulated. To identify new loci influencing glycemic
traits, we performed meta-analyses of 21 genome-wide association studies informative for …

Blood pressure is a heritable trait 1 influenced by several biological pathways and responsive
to environmental stimuli. Over one billion people worldwide have hypertension (≥140 mm …

Genome-wide association (GWA) studies have identified multiple loci at which common variants
modestly but reproducibly influence risk of type 2 diabetes (T2D) 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , …

By combining genome-wide association data from 8,130 individuals with type 2 diabetes (T2D)
and 38,987 controls of European descent and following up previously unidentified meta-…

To identify genetic variants influencing plasma lipid concentrations, we first used genotype
imputation and meta-analysis to combine three genome-wide scans totaling 8,816 individuals …

The genetic architecture of common traits, including the number, frequency, and effect sizes
of inherited variants that contribute to individual risk, has been long debated. Genome-wide …