We have profiled promoter DNA methylation alterations in 272 glioblastoma tumors in the
context of The Cancer Genome Atlas (TCGA). We found that a distinct subset of samples …

Determining the genetic basis of cancer requires comprehensive analyses of large collections
of histopathologically well-classified primary tumours. Here we report the results of a …

Background The full complement of DNA mutations that are responsible for the pathogenesis
of acute myeloid leukemia (AML) is not yet known. Methods We used massively parallel …

Most patients with acute myeloid leukaemia (AML) die from progressive disease after relapse,
which is associated with clonal evolution at the cytogenetic level 1 , 2 . To determine the …

Several genetic alterations characteristic of leukemia and lymphoma have been detected in
the blood of individuals without apparent hematological malignancies. The Cancer Genome …

Background The genetic alterations responsible for an adverse outcome in most patients
with acute myeloid leukemia (AML) are unknown. Methods Using massively parallel DNA …

Most mutations in cancer genomes are thought to be acquired after the initiating event,
which may cause genomic instability and drive clonal evolution. However, for acute myeloid …

Massively parallel DNA sequencing technologies provide an unprecedented ability to
screen entire genomes for genetic changes associated with tumour progression. Here we …

Background The myelodysplastic syndromes are a group of hematologic disorders that often
evolve into secondary acute myeloid leukemia (AML). The genetic changes that underlie …

‘Orang-utan’ is derived from a Malay term meaning ‘man of the forest’ and aptly describes the
southeast Asian great apes native to Sumatra and Borneo. The orang-utan species, Pongo …