In the zebrafish (Danio rerio), regeneration and fibrosis after cardiac injury are not mutually
exclusive responses. Upon cardiac cryoinjury, collagen and other extracellular matrix (ECM) …

Cardiac valve disease can lead to severe cardiac dysfunction and is thus a frequent cause
of morbidity and mortality. Its main treatment is valve replacement, which is currently greatly …

During development, mesodermal progenitors from the first heart field (FHF) form a primitive
cardiac tube, to which progenitors from the second heart field (SHF) are added. The …

In this work, we quantify the mechanical properties of the extra-cellular matrix (ECM) in live
zebrafish using Brillouin microscopy. Optimization of the imaging conditions and parameters, …

CRISPR/Cas9-mediated targeted mutagenesis allows efficient generation of loss-of-function
alleles in zebrafish. To date, this technology has been primarily used to generate genetic …

Conditional mutagenesis using Cre recombinase expressed from tissue specific promoters
facilitates analyses of gene function and cell lineage tracing. Here, we describe two novel …

Myocardial infarction (MI) is a leading cause of death worldwide. Reperfusion is considered
as an optimal therapy following cardiac ischemia. However, the promotion of a rapid …

The mesothelium lines body cavities and surrounds internal organs, widely contributing to
homeostasis and regeneration. Mesothelium disruptions cause visceral anomalies and …

Aims While zebrafish embryos are amenable to in vivo imaging, allowing the study of
morphogenetic processes during development, intravital imaging of adults is hampered by their …

During heart regeneration in the zebrafish, fibrotic tissue is replaced by newly formed
cardiomyocytes derived from preexisting ones. It is unclear whether the heart is composed of …