User profiles for Heeju Noh
 | H. NohAssociate research scientist, Columbia University Verified email at cumc.columbia.edu Cited by 371 |
Network perturbation analysis of gene transcriptional profiles reveals protein targets and mechanism of action of drugs and influenza A viral infection
Genome-wide transcriptional profiling provides a global view of cellular state and how this
state changes under different treatments (eg drugs) or conditions (eg healthy and diseased). …
state changes under different treatments (eg drugs) or conditions (eg healthy and diseased). …
A reliable determination method of stability limits for electrochemical double layer capacitors
A reliable method for the determination of regions of electrochemical stability of electrolytes
for electrochemical double layer capacitors (EDLC) by means of potential window opening …
for electrochemical double layer capacitors (EDLC) by means of potential window opening …
Insights into pH‐induced metabolic switch by flux balance analysis
M Ivarsson, H Noh, M Morbidelli… - Biotechnology …, 2015 - Wiley Online Library
Lactate accumulation in mammalian cell culture is known to impede cellular growth and
productivity. The control of lactate formation and consumption in a hybridoma cell line was …
productivity. The control of lactate formation and consumption in a hybridoma cell line was …
Inferring gene targets of drugs and chemical compounds from gene expression profiles
Motivation: Finding genes which are directly perturbed or targeted by drugs is of great interest
and importance in drug discovery. Several network filtering methods have been created to …
and importance in drug discovery. Several network filtering methods have been created to …
Inborn Errors of Immunity Contribute to the Burden of Skin Disease and Create Opportunities for Improving the Practice of Dermatology
A Colvin, S Youssef, H Noh, J Wright… - Journal of Investigative …, 2024 - Elsevier
Opportunities to improve the clinical management of skin disease are being created by
advances in genomic medicine. Large-scale sequencing increasingly challenges notions about …
advances in genomic medicine. Large-scale sequencing increasingly challenges notions about …
Interrogation of genome-wide, experimentally dissected gene regulatory networks reveals mechanisms underlying dynamic cellular state control
Pooled CRISPRi-mediated silencing of >1,000 transcriptional regulators expressed in single
colorectal adenocarcinoma cells, followed by single-cell RNA-seq profiling at two timepoints…
colorectal adenocarcinoma cells, followed by single-cell RNA-seq profiling at two timepoints…
[HTML][HTML] DeltaNeTS+: elucidating the mechanism of drugs and diseases using gene expression and transcriptional regulatory networks
H Noh, Z Hua, P Chrysinas, JE Shoemaker… - BMC …, 2021 - Springer
Background Knowledge on the molecular targets of diseases and drugs is crucial for elucidating
disease pathogenesis and mechanism of action of drugs, and for driving drug discovery …
disease pathogenesis and mechanism of action of drugs, and for driving drug discovery …
Inferring causal gene targets from time course expression data
In this work, we proposed a network analysis method called DeltaNeTS for inferring genetic
perturbations from temporal transcriptional expression profiles. While several efficacious and …
perturbations from temporal transcriptional expression profiles. While several efficacious and …
Identification and Pharmacological Targeting of Treatment-Resistant, Stem-like Breast Cancer Cells for Combination Therapy
Tumors frequently harbor isogenic yet epigenetically distinct subpopulations of multi-potent
cells with high tumor-initiating potential-often called Cancer Stem-Like Cells (CSLCs). These …
cells with high tumor-initiating potential-often called Cancer Stem-Like Cells (CSLCs). These …
Network insights into improving drug target inference algorithms
To improve the efficacy of drug research and development (R&D), a better understanding of
drug mechanisms of action (MoA) is needed to improve drug discovery. Computational …
drug mechanisms of action (MoA) is needed to improve drug discovery. Computational …