Essentially all cells contain a variety of spatially restricted regions that are important for
carrying out specialized functions. Often, these regions contain specialized transcriptomes that …

Alternative polyadenylation (APA) is a widespread and conserved regulatory mechanism that
generates diverse 3′ ends on mRNA. APA patterns are often tissue specific and play an …

In 1900, Adami speculated that a sequence of context‐independent energetic and structural
changes governed the reversion of differentiated cells to a proliferative, regenerative state. …

We hypothesized that basic helix–loop–helix (bHLH) MIST1 (BHLHA15) is a “scaling factor”
that universally establishes secretory morphology in cells that perform regulated secretion. …

Thousands of RNA species display nonuniform distribution within cells. However, quantification
of the spatial patterns adopted by individual RNAs remains difficult, in part by a lack of …

Human PRPF39 is a homolog of the yeast Prp39 and Prp42 paralogs. We have previously
shown that human PRPF39 forms a homodimer that interacts with the CTD of U1C, mirroring …

The gastric epithelium is often exposed to injurious elements and failure of appropriate
healing predisposes to ulcers, hemorrhage, and ultimately cancer. We examined the gastric …

Cellular RNA is asymmetrically distributed in cells and the regulation of RNA localization is
crucial for proper cellular functions. However, limited chemical tools are available to capture …

Many cells contain spatially defined subcellular regions that perform specialized tasks
enabled by localized proteins. The subcellular distribution of these localized proteins is often …

The subcellular localization of specific RNA molecules promotes localized cellular activity
across a variety of species and cell types. The misregulation of this RNA targeting can result in …