User profiles for Heike Blockus

Heike Blockus

Columbia University - Dept of Neuroscience
Verified email at cumc.columbia.edu
Cited by 1372

Local circuit amplification of spatial selectivity in the hippocampus

T Geiller, S Sadeh, SV Rolotti, H Blockus, B Vancura… - Nature, 2022 - nature.com
Local circuit architecture facilitates the emergence of feature selectivity in the cerebral
cortex 1 . In the hippocampus, it remains unknown whether local computations supported by …

[PDF][PDF] Whole-neuron synaptic mapping reveals spatially precise excitatory/inhibitory balance limiting dendritic and somatic spiking

…, M Doron, H Chen, V Andreu, F Goudy, H Blockus… - Neuron, 2020 - cell.com
The balance between excitatory and inhibitory (E and I) synapses is thought to be critical for
information processing in neural circuits. However, little is known about the spatial principles …

Slit-robo signaling

H Blockus, A Chédotal - Development, 2016 - journals.biologists.com
Slits are secreted proteins that bind to Roundabout (Robo) receptors. Slit-Robo signaling is
best known for mediating axon repulsion in the developing nervous system. However, in …

[PDF][PDF] Reorganization of CA1 dendritic dynamics by hippocampal sharp-wave ripples during learning

SV Rolotti, H Blockus, FT Sparks, JB Priestley… - Neuron, 2022 - cell.com
The hippocampus plays a critical role in memory consolidation, mediated by coordinated
network activity during sharp-wave ripple (SWR) events. Despite the link between SWRs and …

Compartment-specific tuning of dendritic feature selectivity by intracellular Ca2+ release

…, SA Herrlinger, Y Hirabayashi, VL Hewitt, H Blockus… - Science, 2022 - science.org
Dendritic calcium signaling is central to neural plasticity mechanisms that allow animals to
adapt to the environment. Intracellular calcium release (ICR) from the endoplasmic reticulum …

The multifaceted roles of Slits and Robos in cortical circuits: from proliferation to axon guidance and neurological diseases

H Blockus, A Chédotal - Current opinion in neurobiology, 2014 - Elsevier
Highlights • Slit–Robo guide thalamocortical projections from their birthplace to the cortex. •
Slit–Robo regulate radial as well as tangential migration of cortical neurons. • Slit–Robo …

Preconfigured dynamics in the hippocampus are guided by embryonic birthdate and rate of neurogenesis

R Huszár, Y Zhang, H Blockus, G Buzsáki - Nature neuroscience, 2022 - nature.com
The incorporation of new information into the hippocampal network is likely to be constrained
by its innate architecture and internally generated activity patterns. However, the origin, …

[PDF][PDF] Signaling switch of the axon guidance receptor Robo3 during vertebrate evolution

P Zelina, H Blockus, Y Zagar, A Péres, F Friocourt… - Neuron, 2014 - cell.com
Development of neuronal circuits is controlled by evolutionarily conserved axon guidance
molecules, including Slits, the repulsive ligands for roundabout (Robo) receptors, and Netrin-1…

[PDF][PDF] Local feedback inhibition tightly controls rapid formation of hippocampal place fields

…, M Szoboszlay, T Geiller, A Negrean, H Blockus… - Neuron, 2022 - cell.com
Hippocampal place cells underlie spatial navigation and memory. Remarkably, CA1 pyramidal
neurons can form new place fields within a single trial by undergoing rapid plasticity. …

[PDF][PDF] Activity-dependent nucleation of dynamic microtubules at presynaptic boutons controls neurotransmission

X Qu, A Kumar, H Blockus, C Waites, F Bartolini - Current biology, 2019 - cell.com
Control of microtubule (MT) nucleation and dynamics is critical for neuronal function. Whether
MT nucleation is regulated at presynaptic boutons and influences overall presynaptic …