User profiles for Heike Blockus
Heike BlockusColumbia University - Dept of Neuroscience Verified email at cumc.columbia.edu Cited by 1372 |
Local circuit amplification of spatial selectivity in the hippocampus
Local circuit architecture facilitates the emergence of feature selectivity in the cerebral
cortex 1 . In the hippocampus, it remains unknown whether local computations supported by …
cortex 1 . In the hippocampus, it remains unknown whether local computations supported by …
[PDF][PDF] Whole-neuron synaptic mapping reveals spatially precise excitatory/inhibitory balance limiting dendritic and somatic spiking
The balance between excitatory and inhibitory (E and I) synapses is thought to be critical for
information processing in neural circuits. However, little is known about the spatial principles …
information processing in neural circuits. However, little is known about the spatial principles …
Slit-robo signaling
H Blockus, A Chédotal - Development, 2016 - journals.biologists.com
Slits are secreted proteins that bind to Roundabout (Robo) receptors. Slit-Robo signaling is
best known for mediating axon repulsion in the developing nervous system. However, in …
best known for mediating axon repulsion in the developing nervous system. However, in …
[PDF][PDF] Reorganization of CA1 dendritic dynamics by hippocampal sharp-wave ripples during learning
The hippocampus plays a critical role in memory consolidation, mediated by coordinated
network activity during sharp-wave ripple (SWR) events. Despite the link between SWRs and …
network activity during sharp-wave ripple (SWR) events. Despite the link between SWRs and …
Compartment-specific tuning of dendritic feature selectivity by intracellular Ca2+ release
Dendritic calcium signaling is central to neural plasticity mechanisms that allow animals to
adapt to the environment. Intracellular calcium release (ICR) from the endoplasmic reticulum …
adapt to the environment. Intracellular calcium release (ICR) from the endoplasmic reticulum …
The multifaceted roles of Slits and Robos in cortical circuits: from proliferation to axon guidance and neurological diseases
H Blockus, A Chédotal - Current opinion in neurobiology, 2014 - Elsevier
Highlights • Slit–Robo guide thalamocortical projections from their birthplace to the cortex. •
Slit–Robo regulate radial as well as tangential migration of cortical neurons. • Slit–Robo …
Slit–Robo regulate radial as well as tangential migration of cortical neurons. • Slit–Robo …
Preconfigured dynamics in the hippocampus are guided by embryonic birthdate and rate of neurogenesis
The incorporation of new information into the hippocampal network is likely to be constrained
by its innate architecture and internally generated activity patterns. However, the origin, …
by its innate architecture and internally generated activity patterns. However, the origin, …
[PDF][PDF] Signaling switch of the axon guidance receptor Robo3 during vertebrate evolution
P Zelina, H Blockus, Y Zagar, A Péres, F Friocourt… - Neuron, 2014 - cell.com
Development of neuronal circuits is controlled by evolutionarily conserved axon guidance
molecules, including Slits, the repulsive ligands for roundabout (Robo) receptors, and Netrin-1…
molecules, including Slits, the repulsive ligands for roundabout (Robo) receptors, and Netrin-1…
[PDF][PDF] Local feedback inhibition tightly controls rapid formation of hippocampal place fields
Hippocampal place cells underlie spatial navigation and memory. Remarkably, CA1 pyramidal
neurons can form new place fields within a single trial by undergoing rapid plasticity. …
neurons can form new place fields within a single trial by undergoing rapid plasticity. …
[PDF][PDF] Activity-dependent nucleation of dynamic microtubules at presynaptic boutons controls neurotransmission
Control of microtubule (MT) nucleation and dynamics is critical for neuronal function. Whether
MT nucleation is regulated at presynaptic boutons and influences overall presynaptic …
MT nucleation is regulated at presynaptic boutons and influences overall presynaptic …