Pax genes have been shown to play important roles in mammalian development and
organogenesis. Pax9, a member of this transcription factor family, is expressed in somites, …

The composite structure of the mammalian skull, which forms predominantly via
intramembranous ossification, requires precise pre-and post-natal growth regulation of individual …

Haploinsufficiency for human EYA1, a homologue of the Drosophila melanogaster gene
eyes absent (eya), results in the dominantly inherited disorders branchio-oto-renal (BOR) …

Aging is an inherently stochastic process, and its hallmark is heterogeneity between
organisms, cell types, and clonal populations, even in identical environments. The replicative …

Vertebrate organogenesis is initiated at sites that are often morphologically indistinguishable
from the surrounding region. Here we have identified Pax9 as a marker for prospective …

Telomerase is a ribonucleoprotein that counteracts telomere shortening and can immortalise
human cells. There is also evidence for a telomere-independent survival function of …

Organs have to develop at precisely determined sites to ensure functionality of the whole
organism. Organogenesis is typically regulated by a series of interactions between …

Understanding the molecular mechanism by which pluripotency is maintained in human
embryonic stem cells (hESC) is important for the development of improved methods to derive, …

The paralogous genes Pax1 and Pax9 constitute one group within the vertebrate Pax gene
family. They encode closely related transcription factors and are expressed in similar …

Eyes absent (Eya) genes regulate organogenesis in both vertebrates and invertebrates.
Mutations in human EYA1 cause congenital Branchio-Oto-Renal (BOR) syndrome, while …