NEUROTRANSMITTER release is potently blocked by a group of structurally related toxin
proteins produced by Clostridium botulinum 1 . Botulinum neurotoxin type B (BoNT/B) and …

Tetanus toxin cleaves the synaptic vesicle protein synaptobrevin, and the ensuing loss of
neurotransmitter exocytosis has implicated synaptobrevin in this process. To further the study …

Clostridial neurotoxins inhibit neurotransmitter release by selective and specific intracellular
proteolysis of synaptobrevin/VAMP, synaptosomal‐associated protein of 25 kDa (SNAP‐25) …

TETANUS toxin inhibits neurotransmitter release by selectively blocking fusion of synaptic
vesicles 1,2 . Recently tetanus toxin was shown to proteolytically degrade synaptobrevin II (…

Clostridial neurotoxins, tetanus toxin (TeTx) and the seven related but serologically distinct
botulinal neurotoxins (BoNT/A to BoNT/G), are potent inhibitors of synaptic vesicle exocytosis …

The large offspring syndrome (LOS) is observed in bovine and ovine offspring following
transfer of in vitro-produced (IVP) or cloned embryos and is characterized by a multitude of …

Zinc-finger nucleases (ZFNs) are powerful tools for producing gene knockouts (KOs) with
high efficiency. Whereas ZFN-mediated gene disruption has been demonstrated in laboratory …

Tetanus toxin is a potent neurotoxin that inhibits the release of neurotransmitters from
presynaptic nerve endings. The mature toxin is composed of a heavy and a light chain that are …

This study was an investigation of metabolism during bovine preimplantation development
from the oocyte up to the hatched blastocyst derived in vitro or in vivo. Metabolism was …

The importance of soluble N-ethyl maleimide (NEM)-sensitive fusion protein (NSF) attachment
protein (SNAP) receptors (SNAREs) in synaptic vesicle exocytosis is well established …