User profiles for Helen E Bryant
 | Helen E BryantUniversity of Sheffield Verified email at sheffield.ac.uk Cited by 13178 |
Specific killing of BRCA2-deficient tumours with inhibitors of poly (ADP-ribose) polymerase
Poly(ADP-ribose) polymerase (PARP1) facilitates DNA repair by binding to DNA breaks and
attracting DNA repair proteins to the site of damage 1 , 2 , 3 . Nevertheless, PARP1 -/- mice …
attracting DNA repair proteins to the site of damage 1 , 2 , 3 . Nevertheless, PARP1 -/- mice …
PARP is activated at stalled forks to mediate Mre11‐dependent replication restart and recombination
If replication forks are perturbed, a multifaceted response including several DNA repair and
cell cycle checkpoint pathways is activated to ensure faithful DNA replication. Here, we show …
cell cycle checkpoint pathways is activated to ensure faithful DNA replication. Here, we show …
[HTML][HTML] Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer
Introduction Breast cancer remains a significant scientific, clinical and societal challenge.
This gap analysis has reviewed and critically assessed enduring issues and new challenges …
This gap analysis has reviewed and critically assessed enduring issues and new challenges …
Spontaneous homologous recombination is induced by collapsed replication forks that are caused by endogenous DNA single-strand breaks
Homologous recombination is vital to repair fatal DNA damage during DNA replication.
However, very little is known about the substrates or repair pathways for homologous …
However, very little is known about the substrates or repair pathways for homologous …
Transition metal complexes as photosensitisers in one-and two-photon photodynamic therapy
Photodynamic therapy (PDT) exploits light-activated compounds for therapeutic use. It relies
on a photosensitiser (PS) that is inactive in the absence of light. When irradiated, the PS …
on a photosensitiser (PS) that is inactive in the absence of light. When irradiated, the PS …
Reduced expression of miRNA-27a modulates cisplatin resistance in bladder cancer by targeting the cystine/glutamate exchanger SLC7A11
…, S Peter, S Bertz, A Hartmann, HE Bryant… - Clinical cancer …, 2014 - AACR
Purpose: Resistance to cisplatin-based chemotherapy is a major obstacle to bladder cancer
treatment. We aimed to identify microRNAs (miRNA) that are dysregulated in cisplatin-…
treatment. We aimed to identify microRNAs (miRNA) that are dysregulated in cisplatin-…
Poly (ADP-Ribose) polymerase is hyperactivated in homologous recombination–defective cells
Poly(ADP-ribose) (PAR) polymerase 1 (PARP1) is activated by DNA single-strand breaks (SSB)
or at stalled replication forks to facilitate DNA repair. Inhibitors of PARP efficiently kill …
or at stalled replication forks to facilitate DNA repair. Inhibitors of PARP efficiently kill …
PI3King the lock: targeting the PI3K/Akt/mTOR pathway as a novel therapeutic strategy in neuroblastoma
Neuroblastoma is the most common extracranial cancer in childhood. High-risk neuroblastoma
continues to have a poor prognosis and there is an urgent need to design biologically …
continues to have a poor prognosis and there is an urgent need to design biologically …
Poly (ADP-ribose) polymerase (PARP-1) in homologous recombination and as a target for cancer therapy
Poly(ADP-ribose) polymerase (PARP-1) binds to DNA breaks to facilitate DNA repair. However,
the role of PARP-1 in DNA repair appears to not be critical since PARP-1 knockout mice …
the role of PARP-1 in DNA repair appears to not be critical since PARP-1 knockout mice …
[HTML][HTML] DNA repair in prostate cancer: biology and clinical implications
Context For more precise, personalized care in prostate cancer (PC), a new classification
based on molecular features relevant for prognostication and treatment stratification is needed. …
based on molecular features relevant for prognostication and treatment stratification is needed. …