User profiles for Helen L. Fillmore

Helen L Fillmore

University of Portsmouth
Verified email at port.ac.uk
Cited by 4541

The regulation and function of lactate dehydrogenase a: therapeutic potential in brain tumor

CJ Valvona, HL Fillmore, PB Nunn… - Brain …, 2016 - Wiley Online Library
There are over 120 types of brain tumor and approximately 45% of primary brain tumors are
gliomas, of which glioblastoma multiforme ( GBM ) is the most common and aggressive with …

In vitro angiogenesis by human umbilical vein endothelial cells (HUVEC) induced by three-dimensional co-culture with glioblastoma cells

…, A Htay, WD Santos, GT Gillies, HL Fillmore… - Journal of neuro …, 2009 - Springer
Glioblastoma multiforme (GBM) is one of the most highly vascularized of all human tumors.
Our objective was to characterize a 3-dimensional (3-D) in vitro angiogenesis model by co-…

Membrane-type matrix metalloproteinases (MT-MMP) s: expression and function during glioma invasion

HL Fillmore, TE VanMeter, WC Broaddus - Journal of neuro-oncology, 2001 - Springer
Membrane-type MMPs (MT-MMPs) constitute a growing subclass of recently identified matrix
metalloproteinases (MMPs). In addition to the highly conserved MMP functional domains, …

The role of matrix metalloproteinase genes in glioma invasion: co-dependent and interactive proteolysis

…, HK Rooprai, MM Kibble, HL Fillmore… - Journal of neuro …, 2001 - Springer
Matrix metalloproteinases (MMPs) are cation-dependent endopeptidases which have been
implicated in the malignancy of gliomas. It is thought that the MMPs play a critical role in both …

Stem cell biology in traumatic brain injury: effects of injury and strategies for repair: a review

RM Richardson, A Singh, D Sun, HL Fillmore… - Journal of …, 2010 - thejns.org
Approximately 350,000 individuals in the US are affected annually by severe and moderate
traumatic brain injuries (TBI) that may result in long-term disability. This rate of injury has …

Encapsulation of a Radiolabeled Cluster Inside a Fullerene Cage, 177LuxLu(3−x)N@C80: An Interleukin-13-Conjugated Radiolabeled Metallofullerene Platform

…, J Ge, J Zhang, HW Gibson, HL Fillmore… - Journal of the …, 2010 - ACS Publications
In this communication, we describe the successful encapsulation of 177 Lu into the
endohedral metallofullerene 177 Lu x Lu 3−x N@C 80 (x = 1−3) starting with 177 LuCl 3 in a …

Conjugation of functionalized gadolinium metallofullerenes with IL-13 peptides for targeting and imaging glial tumors

HL Fillmore, MD Shultz, SC Henderson, P Cooper… - …, 2011 - Future Medicine
Background: Glioblastoma multiforme is the most common and most lethal primary brain
tumor in humans, with median survival of approximately 1 year. Owing to the ability of glioma …

[HTML][HTML] Real-time acquisition of transendothelial electrical resistance in an all-human, in vitro, 3-dimensional, blood–brain barrier model exemplifies tight-junction …

Z Maherally, HL Fillmore, SL Tan, SF Tan… - The FASEB …, 2018 - ncbi.nlm.nih.gov
The blood–brain barrier (BBB) consists of endothelial cells, astrocytes, and pericytes
embedded in basal lamina (BL). Most in vitro models use nonhuman, monolayer cultures for …

[HTML][HTML] Oxamate, but not selective targeting of LDH-A, inhibits medulloblastoma cell glycolysis, growth and motility

CJ Valvona, HL Fillmore - Brain sciences, 2018 - mdpi.com
Medulloblastoma is the most common malignant paediatric brain tumour and current therapies
often leave patients with severe neurological disabilities. Four major molecular groups of …

Grafts of adult subependymal zone neuronal progenitor cells rescue hemiparkinsonian behavioral decline

…, WC Broaddus, KL Holloway, HL Fillmore - Brain research, 2005 - Elsevier
Neuronal progenitor cells (NPCs) residing in the adult subependymal zone (SEZ) are a
potential source of expandable cells for autologous transplantation to treat Parkinson's Disease …