Increased production of reactive oxygen species (ROS) has long been considered a cause
of aging. However, recent studies have implicated ROS as essential secondary messengers. …

Current investigations show that layered double hydroxide (LDH) nanoparticles have high
potential as effective non-viral agents for cellular drug delivery due to their low cytotoxicity, …

Ryk (receptor related to tyrosine kinase) has been shown to be a novel Wnt receptor in both
Caenorhabditis elegans and Drosophila melanogaster. Recently, Ryk–Wnt interactions …

The integrin alpha 6 beta 4 is a heterodimer predominantly expressed by epithelia. While
no definite receptor function has yet been assigned to it, this integrin may mediate adhesive …

The human gene POLG encodes the catalytic subunit of mitochondrial DNA polymerase,
but its precise roles in mtDNA metabolism in vivo have not hitherto been documented. By …

Many epithelial cells appear to use cell-substratum adhesion complexes known as
hemidesmosomes as the main means of anchorage to the connective tissue. Initially recognized as …

Small interfering RNAs (siRNAs) are capable of targeting and destroying specific mRNAs,
making them particularly suited to the treatment of neurodegenerative conditions such as …

Pharmaceutical and agrochemical discovery programs are under considerable pressure to
meet increasing global demand and thus require constant innovation. Classical hydrocarbon …

We prepared stable homogeneous suspensions with layered double hydroxide (LDH)
nanoparticles for in vitro gene delivery tests. The viability of HEK 293T cells in the presence of …

Mutations in the mitochondrial helicase Twinkle underlie autosomal dominant progressive
external ophthalmoplegia (PEO), as well as recessively inherited infantile-onset …