User profiles for Helena Urquijo

Helena Urquijo

University of Bristol
Verified email at bristol.ac.uk
Cited by 27

[HTML][HTML] A lifecourse mendelian randomization study highlights the long-term influence of childhood body size on later life heart structure

K O'Nunain, C Park, H Urquijo, GM Leyden… - PLoS …, 2022 - journals.plos.org
Children with obesity typically have larger left ventricular heart dimensions during adulthood.
However, whether this is due to a persistent effect of adiposity extending into adulthood is …

[HTML][HTML] Investigating effect modification between childhood maltreatment and genetic risk for cardiovascular disease in the UK Biobank

H Urquijo, AG Soares, A Fraser, LD Howe, AR Carter - PLoS one, 2023 - journals.plos.org
Cardiovascular disease (CVD) is influenced by genetic and environmental factors.
Childhood maltreatment is associated with CVD and may modify genetic susceptibility to …

[HTML][HTML] Leveraging family history data to disentangle time-varying effects on disease risk using lifecourse mendelian randomization

TG Richardson, H Urquijo, MV Holmes… - European Journal of …, 2023 - Springer
Lifecourse Mendelian randomization is a causal inference technique which harnesses
genetic variants with time-varying effects to develop insight into the influence of age-dependent …

Glucocorticoids regulate mitochondrial fatty acid oxidation in fetal cardiomyocytes

…, JF Zhao, C Buckley, H Urquijo… - The Journal of …, 2021 - Wiley Online Library
The late gestational rise in glucocorticoids contributes to the structural and functional maturation
of the perinatal heart. Here, we hypothesized that glucocorticoid action contributes to …

Characterizing the Causal Pathway From Childhood Adiposity to Right Heart Physiology and Pulmonary Circulation Using Lifecourse Mendelian Randomization

GM Leyden, H Urquijo, AD Hughes… - Journal of the …, 2024 - Am Heart Assoc
Background Observational epidemiological studies have reported an association between
childhood adiposity and altered cardiac morphology and function in later life. However, …

[PDF][PDF] A lifecourse Mendelian randomization study uncovers age-dependent effects of adiposity on asthma risk

H Urquijo, GM Leyden, GD Smith, TG Richardson - Iscience, 2023 - cell.com
Evaluating the long-term consequences of childhood lifestyle factors on asthma risk can be
exceptionally challenging in epidemiology given that cases are typically diagnosed at …

Effects of childhood and adult height on later life cardiovascular disease risk estimated through Mendelian randomization

TG Richardson, H Urquijo, LJ Howe, G Hawkes… - medRxiv, 2023 - medrxiv.org
Background: Taller individuals are at elevated and protected risk of various cardiovascular
disease endpoints. Whether this is due to a direct consequence of their height during …

Age-dependent effects of adiposity on asthma risk during childhood and adulthood: a lifecourse Mendelian randomization study

H Urquijo, GM Leyden, G Davey Smith, TG Richardson - medRxiv, 2023 - medrxiv.org
Background: Separating the direct and long-term consequences of childhood lifestyle factors
on asthma risk can be exceptionally challenging in epidemiology given that cases are …

Investigating childhood maltreatment as a modifier of genetic risk for cardiovascular disease in the UK Biobank

H Urquijo, AG Soares, A Fraser, LD Howe, AR Carter - medRxiv, 2022 - medrxiv.org
Cardiovascular disease (CVD) is influenced by genetic and environmental factors.
Childhood maltreatment is associated with CVD and may modify genetic susceptibility to …

Glucocorticoid receptor activation regulates cardiomyocyte cell cycle in neonates

J Ivy, H Urquijo, R Mort, K Chapman - Endocrine Abstracts, 2021 - endocrine-abstracts.org
In neonates, cardiomyocytes exit the cell cycle thus establishing cardiomyocyte number for
life. Further growth is through hypertrophy. Factors that advance the timing of the switch from …