User profiles for Helena Urquijo
Helena UrquijoUniversity of Bristol Verified email at bristol.ac.uk Cited by 27 |
[HTML][HTML] A lifecourse mendelian randomization study highlights the long-term influence of childhood body size on later life heart structure
K O'Nunain, C Park, H Urquijo, GM Leyden… - PLoS …, 2022 - journals.plos.org
Children with obesity typically have larger left ventricular heart dimensions during adulthood.
However, whether this is due to a persistent effect of adiposity extending into adulthood is …
However, whether this is due to a persistent effect of adiposity extending into adulthood is …
[HTML][HTML] Investigating effect modification between childhood maltreatment and genetic risk for cardiovascular disease in the UK Biobank
Cardiovascular disease (CVD) is influenced by genetic and environmental factors.
Childhood maltreatment is associated with CVD and may modify genetic susceptibility to …
Childhood maltreatment is associated with CVD and may modify genetic susceptibility to …
[HTML][HTML] Leveraging family history data to disentangle time-varying effects on disease risk using lifecourse mendelian randomization
Lifecourse Mendelian randomization is a causal inference technique which harnesses
genetic variants with time-varying effects to develop insight into the influence of age-dependent …
genetic variants with time-varying effects to develop insight into the influence of age-dependent …
Glucocorticoids regulate mitochondrial fatty acid oxidation in fetal cardiomyocytes
The late gestational rise in glucocorticoids contributes to the structural and functional maturation
of the perinatal heart. Here, we hypothesized that glucocorticoid action contributes to …
of the perinatal heart. Here, we hypothesized that glucocorticoid action contributes to …
Characterizing the Causal Pathway From Childhood Adiposity to Right Heart Physiology and Pulmonary Circulation Using Lifecourse Mendelian Randomization
Background Observational epidemiological studies have reported an association between
childhood adiposity and altered cardiac morphology and function in later life. However, …
childhood adiposity and altered cardiac morphology and function in later life. However, …
[PDF][PDF] A lifecourse Mendelian randomization study uncovers age-dependent effects of adiposity on asthma risk
H Urquijo, GM Leyden, GD Smith, TG Richardson - Iscience, 2023 - cell.com
Evaluating the long-term consequences of childhood lifestyle factors on asthma risk can be
exceptionally challenging in epidemiology given that cases are typically diagnosed at …
exceptionally challenging in epidemiology given that cases are typically diagnosed at …
Effects of childhood and adult height on later life cardiovascular disease risk estimated through Mendelian randomization
Background: Taller individuals are at elevated and protected risk of various cardiovascular
disease endpoints. Whether this is due to a direct consequence of their height during …
disease endpoints. Whether this is due to a direct consequence of their height during …
Age-dependent effects of adiposity on asthma risk during childhood and adulthood: a lifecourse Mendelian randomization study
H Urquijo, GM Leyden, G Davey Smith, TG Richardson - medRxiv, 2023 - medrxiv.org
Background: Separating the direct and long-term consequences of childhood lifestyle factors
on asthma risk can be exceptionally challenging in epidemiology given that cases are …
on asthma risk can be exceptionally challenging in epidemiology given that cases are …
Investigating childhood maltreatment as a modifier of genetic risk for cardiovascular disease in the UK Biobank
Cardiovascular disease (CVD) is influenced by genetic and environmental factors.
Childhood maltreatment is associated with CVD and may modify genetic susceptibility to …
Childhood maltreatment is associated with CVD and may modify genetic susceptibility to …
Glucocorticoid receptor activation regulates cardiomyocyte cell cycle in neonates
In neonates, cardiomyocytes exit the cell cycle thus establishing cardiomyocyte number for
life. Further growth is through hypertrophy. Factors that advance the timing of the switch from …
life. Further growth is through hypertrophy. Factors that advance the timing of the switch from …