Stromal stiffening accompanies malignancy, compromises treatment and promotes tumour
aggression. Clarifying the molecular nature and the factors that regulate stromal stiffening in …

Triple negative breast cancer (TNBC) is a deadly form of breast cancer due to the development
of resistance to chemotherapy affecting over 30% of patients. New therapeutics and …

Drug-resistant cancer cells represent a major barrier to remission for patients with cancer.
Here we show that drug-induced metabolic perturbation and epigenetic states enable evasion …

DNA double‐strand breaks ( DSB s) can be repaired by two major pathways: non‐homologous
end‐joining ( NHEJ ) and homologous recombination ( HR ). DNA repair pathway choice …

Simple Summary In breast cancer, there is a high degree of variability in tumors and the
surrounding tissue called the tumor microenvironment (TME). To better understand tumor …

Circulating nucleic acids are found in free form in body fluids and may serve as minimally
invasive tools for cancer diagnosis and prognosis. Only a few studies have investigated the …

… Hellen Kuasne; Hellen Kuasne … Cliffe, Yibo Xue, Hellen Kuasne, Qinghao Li, Sungmi Jung,
Anne V. Gonzalez, Sophie Camilleri-Broet, Marie-Christine Guiot, Morag Park, Josie Ursini-…

Hypoxia is an important phenomenon in solid tumors that contributes to metastasis, tumor
microenvironment (TME) deregulation, and resistance to therapies. The receptor tyrosine …

In triple-negative breast cancer (TNBC), stromal restriction of CD8 + T cells associates with
poor clinical outcomes and lack of responsiveness to immune-checkpoint blockade (ICB). To …

Background Despite penile carcinoma (PeCa) being a relatively rare neoplasm, it remains
an important public health issue for poor and developing countries. Contrary to most tumors, …