Aim To review published evidence on the effects of arteriolar changes in primary and
secondary hypertension. Background Pressure profile analyses have shown that the …

To test the hypothesis that continuous intrarenal norepinephrine (NE) infusions produce
hypertension via activation of afferent renal nerves (ARN), rats were subjected to complete renal …

Rationale: Hypertension is a major risk factor for cerebral small vessel disease, the most
prevalent cause of vascular cognitive impairment. As we have shown, hypertension induced by …

Early blockade of the renin–angiotensin system is successful in delaying the development
of hypertension in spontaneously hypertensive rats (SHRs) and ameliorating organ damage …

Tumors need to acquire an angiogenic phenotype for outgrowth and metastasis formation.
Limited information on the angiogenic potential of specific tissues, especially human breast …

In the present study we examined sympathetic function and baroreceptor reflex sensitivity in
adult spontaneously hypertensive rats (SHR) after a selective transection of afferent renal …

Increased vascular resistance in spontaneous hypertension has been attributed to a reduced
arteriolar lumen and a decrease in the number of arterioles and capillaries. In the present …

Several methods have been used to evaluate the elastic modulus of the aortic wall in the rat,
but these have never been compared when used simultaneously. We measured …

Intrapericardial application of therapeutic agents may open perspectives for target-directed
therapy of the diseased heart. This study was performed to investigate whether …

In small arteries, a chronic blood flow reduction leads to inward hypotrophic remodeling,
while a chronic blood flow elevation induces outward hypertrophic remodeling. The RhoA/Rho …