The vascular barrier that separates blood from tissues is actively regulated by the endothelium
and is essential for transport, inflammation, and haemostasis 1. Haemodynamic shear …

Hematopoietic stem cells (HSCs) reside within a specialized niche where interactions with
vasculature, osteoblasts, and stromal components regulate their self-renewal and …

Objective— The calcium composition of atherosclerotic plaque is thought to be associated
with increased risk for cardiovascular events, but whether plaque calcium itself is predictive of …

Delineating the mechanism or mechanisms that regulate the specification of hemogenic
endothelial cells from primordial endothelium is critical for optimizing their derivation from …

Asthma, the prototypic Th2-mediated inflammatory disorder of the lung, is an emergent disease
worldwide. Vascular endothelial growth factor (VEGF) is a critical regulator of pulmonary …

During blood vessel development, endothelial cells become specified toward arterial or
venous fates to generate a circulatory network that provides nutrients and oxygen to, and …

Connexin37-mediated regulation of cell cycle modulators and, consequently, growth arrest
lack mechanistic understanding. We previously showed that arterial shear stress up-…

Hox genes are sequence-specific DNA transcription factors, which are important in
embryonic development and are expressed in a number of fetal tissues, including the lung. …

The subventricular zone (SVZ) is the largest neural stem cell (NSC) niche in the adult brain;
herein, the blood-brain barrier is leaky, allowing direct interactions between NSCs and …

Development of blood-forming (hemogenic) endothelial cells that give rise to hematopoietic
stem and progenitor cells (HSPCs) is critical during embryogenesis to generate the …