G protein-coupled receptors (GPCRs) are major signal recognition and transmission units in
the plasma membrane. The interaction of activated and phosphorylated GPCRs with the …

Desensitization, signaling, and trafficking of G-protein-coupled receptors (GPCRs) are
critically regulated by multifunctional adaptor proteins, β-arrestins (βarrs). The two isoforms of …

Beta-arrestins (βarrs) critically mediate desensitization, endocytosis and signalling of G
protein-coupled receptors (GPCRs), and they scaffold a large number of interaction partners. …

The human complement component, C5a, binds two different seven-transmembrane
receptors termed C5aR1 and C5aR2. C5aR1 is a prototypical G-protein–coupled receptor that …

Recent studies pioneer the existence of a novel programmed cell death pathway in malaria
parasite plasmodium and suggest that it could be helpful in developing new targeted anti-…

Earlier we have reported that reserpine, an antihypertensive drug, known to downregulate
biogenic amines through inhibition of the vesicular monoamine transporter (VMAT), increases …

The present work is focused on the preparation of nanoemulsions (NEs) loaded with arteether
(ART) for its enhanced efficacy against malaria parasites. ART-NEs have been prepared …

The β 1 -adrenoceptor (β 1 AR) is a G-protein-coupled receptor (GPCR) that couples 1 to
the heterotrimeric G protein G s . G-protein-mediated signalling is terminated by …

Biased agonism at G-protein-coupled receptors is generally conceptualized as the ability of
certain stimuli to trigger downstream signaling exclusively through one of two effectors. …

Aging is a debilitating process often associated with chronic diseases such as diabetes,
cardiovascular and neurodegenerative diseases like Alzheimer's disease (AD). AD occurs at a …