User profiles for Hengyao Niu
HENGYAO NIUAssociate Professor, Indiana University Bloomington Verified email at indiana.edu Cited by 4342 |
Deciphering protein kinase specificity through large-scale analysis of yeast phosphorylation site motifs
…, SA Parker, V Desai, M Jwa, E Cameroni, H Niu… - Science …, 2010 - science.org
Phosphorylation is a universal mechanism for regulating cell behavior in eukaryotes. Although
protein kinases target short linear sequence motifs on their substrates, the rules for kinase …
protein kinases target short linear sequence motifs on their substrates, the rules for kinase …
Mechanism of the ATP-dependent DNA end-resection machinery from Saccharomyces cerevisiae
If not properly processed and repaired, DNA double-strand breaks (DSBs) can give rise to
deleterious chromosome rearrangements, which could ultimately lead to the tumour …
deleterious chromosome rearrangements, which could ultimately lead to the tumour …
Pif1 helicase and Polδ promote recombination-coupled DNA synthesis via bubble migration
During DNA repair by homologous recombination (HR), DNA synthesis copies information
from a template DNA molecule. Multiple DNA polymerases have been implicated in repair-…
from a template DNA molecule. Multiple DNA polymerases have been implicated in repair-…
Partner choice during meiosis is regulated by Hop1-promoted dimerization of Mek1
H Niu, L Wan, B Baumgartner, D Schaefer… - Molecular biology of …, 2005 - Am Soc Cell Biol
Meiotic recombination differs from mitotic recombination in that DSBs are repaired using
homologous chromosomes, rather than sister chromatids. This change in partner choice is due …
homologous chromosomes, rather than sister chromatids. This change in partner choice is due …
[PDF][PDF] DNA sequence alignment by microhomology sampling during homologous recombination
Homologous recombination (HR) mediates the exchange of genetic information between
sister or homologous chromatids. During HR, members of the RecA/Rad51 family of …
sister or homologous chromatids. During HR, members of the RecA/Rad51 family of …
Cell cycle regulation of DNA double-strand break end resection by Cdk1-dependent Dna2 phosphorylation
X Chen, H Niu, WH Chung, Z Zhu, A Papusha… - Nature structural & …, 2011 - nature.com
DNA recombination pathways are regulated by the cell cycle to coordinate with replication.
Cyclin-dependent kinase (Cdk1) promotes efficient 5′ strand resection at DNA double-…
Cyclin-dependent kinase (Cdk1) promotes efficient 5′ strand resection at DNA double-…
[PDF][PDF] Concentration-dependent exchange of replication protein A on single-stranded DNA revealed by single-molecule imaging
Replication protein A (RPA) is a ubiquitous eukaryotic single-stranded DNA (ssDNA) binding
protein necessary for all aspects of DNA metabolism involving an ssDNA intermediate, …
protein necessary for all aspects of DNA metabolism involving an ssDNA intermediate, …
[PDF][PDF] Regulation of meiotic recombination via Mek1-mediated Rad54 phosphorylation
A preference for homologs over sister chromatids in homologous recombination is a
fundamental difference in meiotic versus mitotic cells. In budding yeast, the bias for interhomolog …
fundamental difference in meiotic versus mitotic cells. In budding yeast, the bias for interhomolog …
Nucleosome dynamics regulates DNA processing
The repair of DNA double-strand breaks (DSBs) is critical for the maintenance of genome
integrity. The first step in DSB repair by homologous recombination is the processing of the …
integrity. The first step in DSB repair by homologous recombination is the processing of the …
Cdc28–Clb5 (CDK-S) and Cdc7–Dbf4 (DDK) collaborate to initiate meiotic recombination in yeast
S-phase cyclin-dependent kinase Cdc28–Clb5 (CDK-S) and Dbf4-dependent kinase Cdc7–Dbf4
(DDK) are highly conserved kinases well known for their roles in the initiation of DNA …
(DDK) are highly conserved kinases well known for their roles in the initiation of DNA …