User profiles for Hengyao Niu

HENGYAO NIU

Associate Professor, Indiana University Bloomington
Verified email at indiana.edu
Cited by 4342

Deciphering protein kinase specificity through large-scale analysis of yeast phosphorylation site motifs

…, SA Parker, V Desai, M Jwa, E Cameroni, H Niu… - Science …, 2010 - science.org
Phosphorylation is a universal mechanism for regulating cell behavior in eukaryotes. Although
protein kinases target short linear sequence motifs on their substrates, the rules for kinase …

Mechanism of the ATP-dependent DNA end-resection machinery from Saccharomyces cerevisiae

H Niu, WH Chung, Z Zhu, Y Kwon, W Zhao, P Chi… - Nature, 2010 - nature.com
If not properly processed and repaired, DNA double-strand breaks (DSBs) can give rise to
deleterious chromosome rearrangements, which could ultimately lead to the tumour …

Pif1 helicase and Polδ promote recombination-coupled DNA synthesis via bubble migration

MA Wilson, YH Kwon, Y Xu, WH Chung, P Chi, H Niu… - Nature, 2013 - nature.com
During DNA repair by homologous recombination (HR), DNA synthesis copies information
from a template DNA molecule. Multiple DNA polymerases have been implicated in repair-…

Partner choice during meiosis is regulated by Hop1-promoted dimerization of Mek1

H Niu, L Wan, B Baumgartner, D Schaefer… - Molecular biology of …, 2005 - Am Soc Cell Biol
Meiotic recombination differs from mitotic recombination in that DSBs are repaired using
homologous chromosomes, rather than sister chromatids. This change in partner choice is due …

[PDF][PDF] DNA sequence alignment by microhomology sampling during homologous recombination

Z Qi, S Redding, JY Lee, B Gibb, YH Kwon, H Niu… - Cell, 2015 - cell.com
Homologous recombination (HR) mediates the exchange of genetic information between
sister or homologous chromatids. During HR, members of the RecA/Rad51 family of …

Cell cycle regulation of DNA double-strand break end resection by Cdk1-dependent Dna2 phosphorylation

X Chen, H Niu, WH Chung, Z Zhu, A Papusha… - Nature structural & …, 2011 - nature.com
DNA recombination pathways are regulated by the cell cycle to coordinate with replication.
Cyclin-dependent kinase (Cdk1) promotes efficient 5′ strand resection at DNA double-…

[PDF][PDF] Concentration-dependent exchange of replication protein A on single-stranded DNA revealed by single-molecule imaging

B Gibb, FY Ling, SC Gergoudis, YH Kwon, H Niu… - Biophysical …, 2014 - cell.com
Replication protein A (RPA) is a ubiquitous eukaryotic single-stranded DNA (ssDNA) binding
protein necessary for all aspects of DNA metabolism involving an ssDNA intermediate, …

[PDF][PDF] Regulation of meiotic recombination via Mek1-mediated Rad54 phosphorylation

H Niu, L Wan, V Busygina, YH Kwon, JA Allen, X Li… - Molecular cell, 2009 - cell.com
A preference for homologs over sister chromatids in homologous recombination is a
fundamental difference in meiotic versus mitotic cells. In budding yeast, the bias for interhomolog …

Nucleosome dynamics regulates DNA processing

NL Adkins, H Niu, P Sung, CL Peterson - Nature structural & molecular …, 2013 - nature.com
The repair of DNA double-strand breaks (DSBs) is critical for the maintenance of genome
integrity. The first step in DSB repair by homologous recombination is the processing of the …

Cdc28–Clb5 (CDK-S) and Cdc7–Dbf4 (DDK) collaborate to initiate meiotic recombination in yeast

L Wan, H Niu, B Futcher, C Zhang… - Genes & …, 2008 - genesdev.cshlp.org
S-phase cyclin-dependent kinase Cdc28–Clb5 (CDK-S) and Dbf4-dependent kinase Cdc7–Dbf4
(DDK) are highly conserved kinases well known for their roles in the initiation of DNA …