The mitochondrial ClpP protease is responsible for mitochondrial protein quality control
through specific degradation of proteins involved in several metabolic processes. ClpP …

We recently described the identification of a new class of small‐molecule activators of the
mitochondrial protease ClpP. These compounds synthesized by Madera Therapeutics showed …

The G protein-coupled receptor (GPCR) smoothened (SMO) is a key signaling component of
the sonic hedgehog (Hh) pathway and a clinically validated target for cancer treatment. The …

Genomics-driven growth in the number of enzymes of unknown function has created a need
for better strategies to characterize them. Since enzyme inhibitors have traditionally served …

The effect on blood pressure and heart rate of central administration of dynorphin A(1 – 13)
and of β-, γ-, and α-endorphin related peptides was studied in urethane-anesthetized rats. …

We have identified and synthesized a series of imidazole containing dimerization inhibitors
of inducible nitric oxide synthase (iNOS). The necessity of key imidazole and piperonyl …

Despite advances in therapy, a significant proportion of patients with chronic lymphocytic
leukemia (CLL) relapse with drug resistant disease. Novel treatment approaches are required, …

Despite advances in treatment, a significant proportion of patients with chronic lymphocytic
leukemia (CLL) will relapse with drug-resistant disease. The imipridones, ONC-201 and ONC-…

The mitochondrial ClpP protease is responsible for mitochondrial protein quality control
through specific degradation of proteins involved in several metabolic processes. ClpP …

NEDERLANDS JURISTENBLAD–14-10-2011–AFL. 35 2369 ming tussen verschillende
politieke partijen normaal gesproken slechts vallen toe te juichen, aangezien die het begrip van …