The cellular interactions that control the differentiation of dorsal cell types from neural progenitors
have been examined in neural plate explants. Certain genes that are expressed in the …

Antibodies that block Sonic Hedgehog (SHH) signaling have been used to show that SHH
activity is required for the induction of floor plate differentiation by the notochord and …

The differentiation of distinct cell types in the ventral neural tube depends on local inductive
signals from the notochord. We have isolated a vertebrate homolog of the Drosophila …

The steroidal alkaloid cyclopamine produces cyclopia and holoprosencephaly when administered
to gastrulation-stage amniote embryos. Cyclopamine-induced malformations in chick …

Characterization of the molecular pathways controlling differentiation and proliferation in
mammalian hair follicles is central to our understanding of the regulation of normal hair growth, …

Near the floor plate of the embryonic neural tube there is a group of neuroepithelial precursor
cells that are specialized for production of the oligodendrocyte lineage. We performed …

The Wnt gene family encodes a group of cysteine-rich proteins implicated in intercellular
signaling during several stages of vertebrate development. This family includes Wnt-1 and Wnt-…

Patched (Ptc) is the ligand-binding component of the Hedgehog (Hh) receptor complex. In
the Drosophila embryo, Ptc and Hh colocalize in vesicular punctate structures. However, …

The hedgehog gene family encodes secreted proteins important in many developmental
patterning events in both vertebrates and invertebrates. In the Drosophila eye disk, hedgehog …

One of the earliest manifestations of anteroposterior pattering in the developing brain is the
restricted expression of Six3 and Irx3 in the anterior and posterior forebrain, respectively. …