Diseases at the molecular level are complex and patient dependent, necessitating development
of strategies that enable precision treatment to optimize clinical outcomes. Organoid …

Mass spectrometry (MS)-based proteomics workflows can crudely be classified into two distinct
regimes, targeting either relatively small peptides (ie, 0.7 kDa < M w < 3.0 kDa) or small …

The original PRIDE Converter tool greatly simplified the process of submitting mass
spectrometry (MS)-based proteomics data to the PRIDE database. However, after much user …

Tumor heterogeneity is a major cause of therapeutic resistance. Immunotherapy may exploit
alternative vulnerabilities of drug-resistant cells, where tumor-specific human leukocyte …

Ion mobility separates molecules in the gas-phase based on their physico-chemical properties,
providing information about their size as collisional cross-sections. The timsTOF Pro …

Human milk is a vital biofluid containing a myriad of molecular components to ensure an
infant’s best start at a healthy life. One key component of human milk is β-casein, a protein …

Genome sequencing of arguably the simplest known animal, Trichoplax adhaerens, uncovered
a rich array of transcription factor and signalling pathway genes. Although the existence …

Staphylococcus aureus is a major cause of infections worldwide, and infection results in a
variety of diseases. As of no surprise, protein phosphorylation is an important game player in …

Quality control is increasingly recognized as a crucial aspect of mass spectrometry based
proteomics. Several recent papers discuss relevant parameters for quality control and present …

cAMP regulates cellular functions primarily by activating PKA. The involvement of PKAs in
various signaling pathways occurring simultaneously in different cellular compartments …