Parkinson’s disease, the most common age-related movement disorder, is a progressive
neurodegenerative disease with unclear etiology. Key neuropathological hallmarks are Lewy …

Pyroptosis is a lytic type of cell death that is initiated by inflammatory caspases. These caspases
are activated within multi‐protein inflammasome complexes that assemble in response …

10.7554/eLife.36402.001 Parkinson’s disease is a progressive neuropathological disorder
that belongs to the class of synucleinopathies, in which the protein alpha-synuclein is found …

The aggregation of proteins into amyloid fibrils is associated with several neurodegenerative
diseases. In Parkinson's disease it is believed that the aggregation of α-synuclein (α-syn) …

ATP synthases are enzymes that can work in two directions to catalyse either the synthesis
or breakdown of ATP, and they constitute the smallest rotary motors in biology. The flow of …

Neurotransmitter-gated ion channels of the Cys-loop receptor family mediate fast
neurotransmission throughout the nervous system. The molecular processes of neurotransmitter …

ABCG2 is a constitutively expressed ATP-binding cassette (ABC) transporter that protects
many tissues against xenobiotic molecules. Its activity affects the pharmacokinetics of …

Physical interactions between proteins are essential for most biological processes governing
life 1 . However, the molecular determinants of such interactions have been challenging to …

Dynamo is a new software package for subtomogram averaging of cryo Electron Tomography
(cryo-ET) data with three main goals: first, Dynamo allows user-transparent adaptation to a …

Two dynamin-related protein (DRP) families are essential for fusion of the outer and inner
mitochondrial membranes, Fzo1 (yeast)/Mfn1/Mfn2 (mammals) and Mgm1 (yeast)/Opa1 (…