Microbiomes are vast communities of microorganisms and viruses that populate all natural
ecosystems. Viruses have been considered to be the most variable component of …

The current dramatic increase of antibiotic resistant bacteria has revitalised the interest in
bacteriophages as alternative antibacterial treatment. Meanwhile, the development of …

Calculating changes in protein stability (ΔΔG) has been shown to be central for predicting
the consequences of single amino acid substitutions in protein engineering as well as …

… Joensen and Henrike Zschach performed the laboratory work. Katrine G. Joensen provided
… Henrike Zschach performed the rest of the data analysis. Henrik Hasman supplied bacterial …

Next-generation sequencing of human genomes reveals millions of missense variants, some
of which may lead to loss of protein function and ultimately disease. Here, we investigate …

crAss-like viruses are a putative family of bacteriophages recently discovered. The eponym
of the clade, crAssphage, is an enteric bacteriophage estimated to be present in at least half …

Staphylococcus aureus is a major agent of nosocomial infections. Especially in methicillin-resistant
strains, conventional treatment options are limited and expensive, which has fueled a …

Objective: Increasing evidence links bacterial dysbiosis with colorectal cancer (CRC)
carcinogenesis, with enrichment of core pathogens such as Bacteroides fragilis and Fusobacterium …

Microbiomes are vast communities of microorganisms and viruses that populate all natural
ecosystems. Viruses have been considered to be the most variable component of …

Bacteriophages, viruses that prey on bacteria, have been applied since the 1920’s to treat
and prevent bacterial infection. After the discovery of antibiotics, this route was however …